ArticleJournal of cardiac failure2016
Serum Bicarbonate in Acute Heart Failure: Relationship to Treatment Strategies and Clinical Outcomes.
Article in Journal of cardiac failure, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Chloride at the spotlight-but not alone: towards a multi-ionic diuretic strategy.Clinical kidney journal · 2026Review
- A Novel Nomogram for Predicting the Risk of Acute Heart Failure in Intensive Care Unit Patients with COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Predicting 30-day and 1-year mortality in heart failure with preserved ejection fraction (HFpEF).PloS one · 2025Article
- Elevated blood bicarbonate levels and long-term adverse outcomes in patients with chronic heart failure.ESC heart failure · 2024Article
- Targeting Sodium in Heart Failure.Journal of personalized medicine · 2024Review
- Development and validation of a novel combinatorial nomogram model to predict in-hospital deaths in heart failure patients.BMC cardiovascular disorders · 2024Article
- Great debate: in patients with decompensated heart failure, acetazolamide in addition to loop diuretics is the first choice.European heart journal · 2023 · on this mapArticle
- Serum Chloride and Heart Failure.Kidney medicine · 2023Review
- Hypochloraemia in Patients with Heart Failure: Causes and Consequences.Cardiology and therapy · 2020Review
- Loop diuretic resistance complicating acute heart failure.Heart failure reviews · 2020Review
- Diuretic Treatment in Heart Failure.The New England journal of medicine · 2017Review
- Pharmacologic Approaches to Electrolyte Abnormalities in Heart Failure.Current heart failure reports · 2016Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThough commonly noted in clinical practice, it is unknown if decongestion in acute heart failure (AHF) results in increased serum bicarbonate. METHODS AND
resultsFor 678 AHF patients in the DOSE-AHF, CARRESS-HF, and ROSE-AHF trials, we assessed change in bicarbonate (baseline to 72-96 hours) according to decongestion strategy, and the relationship between bicarbonate change and protocol-defined decongestion. Median baseline bicarbonate was 28 mEq/L. Patients with baseline bicarbonate ≥28 mEq/L had lower ejection fraction, worse renal function and higher N-terminal pro-B-type natriuretic peptide than those with baseline bicarbonate <28 mEq/L. There were no differences in bicarbonate change between treatment groups in DOSE-AHF or ROSE-AHF (all P > .1). In CARRESS-HF, bicarbonate increased with pharmacologic care but decreased with ultrafiltration (median +3.3 vs -0.9 mEq/L, respectively; P < .001). Bicarbonate change was not associated with successful decongestion (P > .2 for all trials).
conclusionsIn AHF, serum bicarbonate is most commonly elevated in patients with more severe heart failure. Despite being used in clinical practice as an indicator for decongestion, change in serum bicarbonate was not associated with significant decongestion.
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Registered trials
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