Evidence map›Paper›PMID 26777728›Full record

ArticleTrends in immunology2016

Reprogramming the T Cell Response to Tuberculosis.

Joshua S Woodworth, Peter Andersen

Abstract readComment
In one paragraph

Article in Trends in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Immunodominant Tuberculosis Antigens Recognized by Human CD4Cold Spring Harbor perspectives in medicine · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Ag85A-specific CD4Vaccine · 2018
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joshua S WoodworthStatens Serum Institut, Department of Infectious Disease Immunology, Artillerivej 5, 2300 Copenhagen S, Denmark.
Peter AndersenStatens Serum Institut, Department of Infectious Disease Immunology, Artillerivej 5, 2300 Copenhagen S, Denmark. Electronic address: pa@ssi.dk.
Statens Serum Institut · DK

Funding

An adjuvant that promotes TH1/TH17 and CD8 T cells in a tuberculosis vaccineR01AI105422 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L. · 2013 to 2017
$5.1M
NIAID NIH HHS R01 AI105422NIAID NIH HHS R01AI105422
6 · The paper itself

Abstract

Coscolla, Copin et al. recently used comparative genomics of M. tuberculosis (Mtb) strains to show that most human T cell-recognized epitopes are hyperconserved, but bona fide variable epitopes also exist. This identification of two sets of antigens implies opposing evolutionary processes and will have an important impact on tuberculosis (TB) vaccine strategy and design.

Indexed as

Antigens, BacterialEpitopesHumansMycobacterium tuberculosisT-LymphocytesTuberculosisTuberculosis VaccinesAntigens, BacterialEpitopesTuberculosis Vaccines

Identifiers

PMID26777728
PMCPMC4738003
OpenAlexW2232573935

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.