Evidence map›Paper›PMID 26776943›Full record

ArticleJournal of shoulder and elbow surgery2016

Advanced glycation end products in idiopathic frozen shoulders.

Kyu Rim Hwang, George A C Murrell, Neal L Millar, Fiona Bonar, Patrick Lam, Judie R Walton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of shoulder and elbow surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

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  14. The effect of cellular nuclear function alteration on the pathogenesis of shoulder adhesive capsulitis: an immunohistochemical study on lamin A/C expression.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2024
    Article
  15. Hyperglycaemia is a causal risk factor for upper limb pathologies.International journal of epidemiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Kyu Rim HwangOrthopaedic Research Institute, St. George Hospital Campus, University of New South Wales, Sydney, NSW, Australia.
George A C MurrellOrthopaedic Research Institute, St. George Hospital Campus, University of New South Wales, Sydney, NSW, Australia. Electronic address: murrell.g@ori.org.au.
Neal L MillarInstitute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Fiona BonarDouglass Hanly Moir Pathology, Sydney, NSW, Australia.
Patrick LamOrthopaedic Research Institute, St. George Hospital Campus, University of New South Wales, Sydney, NSW, Australia.
Judie R WaltonOrthopaedic Research Institute, St. George Hospital Campus, University of New South Wales, Sydney, NSW, Australia.
UNSW Sydney · AUDouglass Hanly Moir Pathology · AUSydney Orthopaedic Research Institute · AUUniversity of Glasgow · GB

Funding

Wellcome Trust 100651
6 · The paper itself

Abstract

backgroundThe pathophysiologic mechanisms behind proliferation of fibroblasts and deposition of dense collagen matrix in idiopathic frozen shoulder remain unclear. Accumulation of advanced glycation end products (AGEs) with cross-linking and stabilization of collagen has been hypothesized to contribute to this pathophysiologic process. This study investigated whether the immunoreactivity of AGEs is higher in patients with idiopathic frozen shoulder than in the control groups.

methodsShoulder capsule samples were collected from 8 patients with idiopathic frozen shoulder, 6 with unstable shoulders (control 1), and 8 with rotator cuff tears (control 2). The samples were hematoxylin and eosin stained and analyzed by immunohistochemistry using antibodies against AGEs. Immunoreactivities were rated in a blinded fashion from none (0) to strong (3). Immunohistochemical distribution within the capsule was noted.

resultsFrozen shoulder patients had greater frequency and severity of self-reported pain (P = .02) than rotator cuff tear patients and more restricted range of motion in all planes (P < .05) than patients of the instability and rotator cuff tear groups. Hematoxylin and eosin-stained capsular tissue from frozen shoulder showed fibroblastic proliferation, increased numbers of adipocytes, and increased subsynovial vascularity. Immunoreactivity of AGEs was stronger in frozen shoulder capsules (2.8) than in instability (0.3; P = .0001) and rotator cuff tear (1.1; P = .016) capsules.

conclusionThis study highlights a potential role for AGEs in the pathogenesis of frozen shoulder. The overexpression of AGEs may explain the fibroblastic proliferation and deposition of collagen matrix in idiopathic frozen shoulder. LEVEL OF EVIDENCE: Basic Science Study; Histology.

Indexed as

AdipocytesAdolescentAdultAgedBursitisCase-Control StudiesCell CountCell ProliferationFemaleFibroblastsGlycation End Products, AdvancedHumansImmunohistochemistryJoint InstabilityMaleMiddle AgedGlycation End Products, Advancedadhesive capsulitisadvanced glycation end productsfibroblastic proliferationFrozen shoulderimmunoreactivitystiff shoulder

Identifiers

PMID26776943
PMCPMC5402873
OpenAlexW2230372169

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.