ReviewProgress in neuro-psychopharmacology & biological psychiatry2016
The role of monoamine oxidase A in aggression: Current translational developments and future challenges.
Review in Progress in neuro-psychopharmacology & biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 110 citations in OpenAlex.
- Brain network localization of structural and functional abnormality associated with aggression.Translational psychiatry · 2025Article
- Sex-Dependent Effects ofJournal of child sexual abuse · 2025Article
- Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement.Diseases (Basel, Switzerland) · 2024Article
- Association of Interparental Violence and Maternal Depression With Depression Among Adolescents at the Population and Individual Level.JAMA network open · 2023Article
- Factors mitigating the harmful effects of intimate partner violence on adolescents' depressive symptoms-A longitudinal birth cohort study.JCPP advances · 2023Article
- Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetine.Psychopharmacology · 2023Article
- Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD.Biomolecules · 2022Article
- Combined Antagonism of 5-HTPharmaceuticals (Basel, Switzerland) · 2022Article
- Editorial: Role of the serotonergic system in pathology of major depressive disorders.Frontiers in psychiatry · 2022Article
- Prenatal maternal stress and offspring aggressive behavior: Intergenerational and transgenerational inheritance.Frontiers in behavioral neuroscience · 2022Review
- SLC25A24 gene methylation and gray matter volume in females with and without conduct disorder: an exploratory epigenetic neuroimaging study.Translational psychiatry · 2021Article
- DNA methylation and behavioral dysfunction in males with 47,XXY and 49,XXXXY: a pilot study.Clinical epigenetics · 2021Article
- Roles of Hostility and Depression in the Association between the MAOA Gene Polymorphism and Internet Gaming Disorder.International journal of environmental research and public health · 2021Article
- From warrior genes to translational solutions: novel insights into monoamine oxidases (MAOs) and aggression.Translational psychiatry · 2021Review
- Minimally invasive brain injections for viral-mediated transgenesis: New tools for behavioral genetics in sticklebacks.PloS one · 2021Article
- The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men.Progress in neurobiology · 2020Review
- Single-Dose of Testosterone and theFrontiers in behavioral neuroscience · 2020Article
- Gene-environment interactions in antisocial behavior are mediated by early-life 5-HTNeuropharmacology · 2019Article
- Dysfunctional mesocortical dopamine circuit at pre-adolescence is associated to aggressive behavior in MAO-A hypomorphic mice exposed to early life stress.Neuropharmacology · 2019Article
- Amygdala and Hypothalamus: Historical Overview With Focus on Aggression.Neurosurgery · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Drawing upon the recent resurgence of biological criminology, several studies have highlighted a critical role for genetic factors in the ontogeny of antisocial and violent conduct. In particular, converging lines of evidence have documented that these maladaptive manifestations of aggression are influenced by monoamine oxidase A (MAOA), the enzyme that catalyzes the degradation of brain serotonin, norepinephrine and dopamine. The interest on the link between MAOA and aggression was originally sparked by Han Brunner's discovery of a syndrome characterized by marked antisocial behaviors in male carriers of a nonsense mutation of this gene. Subsequent studies showed that MAOA allelic variants associated with low enzyme activity moderate the impact of early-life maltreatment on aggression propensity. In spite of overwhelming evidence pointing to the relationship between MAOA and aggression, the neurobiological substrates of this link remain surprisingly elusive; very little is also known about the interventions that may reduce the severity of pathological aggression in genetically predisposed subjects. Animal models offer a unique experimental tool to investigate these issues; in particular, several lines of transgenic mice harboring total or partial loss-of-function Maoa mutations have been shown to recapitulate numerous psychological and neurofunctional endophenotypes observed in humans. This review summarizes the current knowledge on the link between MAOA and aggression; in particular, we will emphasize how an integrated translational strategy coordinating clinical and preclinical research may prove critical to elucidate important aspects of the pathophysiology of aggression, and identify potential targets for its diagnosis, prevention and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.