SynthesisHPB : the official journal of the International Hepato Pancreato Biliary Association2016
A systematic review of safety and efficacy of hepatopancreatoduodenectomy for biliary and gallbladder cancers.
Synthesis in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Reassessing the Role of Hepatopancreatoduodenectomy in Advanced Biliary Tract Cancer: A Systematic Review and Single-Arm Meta-Analysis of Modern Case Series.Annals of surgical oncology · 2026Pooled it
- Pooled it
- Therapeutic experience of 289 elderly patients with biliary diseases.World journal of gastroenterology · 2017Trial
- Oncologic impact of additional pancreaticoduodenectomy for distal margin-positive perihilar cholangiocarcinoma: a multi-decade single-center analysis.Surgery today · 2026Article
- Changing concepts in perihilar cholangiocarcinoma resections and surgery.International journal of surgery (London, England) · 2026Article
- Robotic Partial Hepatectomy Combined with Pancreaticoduodenectomy for Simultaneous Gallbladder and Common Bile Duct Tumors.Annals of surgical oncology · 2026Article
- Safety and efficacy of pancreaticogastrostomy for hepatopancreatoduodenectomy compared to pancreaticojejunostomy for perihilar cholangiocarcinoma.World journal of surgical oncology · 2025Article
- Laparoscopic hepaticopancreaticoduodenectomy for synchronous intrahepatic cholangiocarcinoma and distal common bile duct tumors: a case report.Frontiers in oncology · 2025Article
- Risk Factors and Prognostic Factors in GBC.Journal of clinical medicine · 2024Review
- Cholangiocarcinoma: The Current Status of Surgical Options including Liver Transplantation.Cancers · 2024Review
- The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative-intent surgery: A 10-year experience in China.Cancer medicine · 2023Article
- Editorial: Surgical Advances in Pancreaticobiliary Diseases.Journal of clinical medicine · 2023Article
- Laparoscopic hepatopancreaticoduodenectomy for synchronous gallbladder cancer and extrahepatic cholangiocarcinoma: a case report.World journal of surgical oncology · 2022Article
- Review
- Current role of hepatopancreatoduodenectomy for the management of gallbladder cancer and extrahepatic cholangiocarcinoma: A systematic review.World journal of gastrointestinal oncology · 2021Article
- Surgical management of biliary malignancy.Current problems in surgery · 2021Article
- Central hepatopancreatoduodenectomy-oncological effectiveness and parenchymal sparing option for diffusely spreading bile duct cancer: report of two cases.BMC surgery · 2021Article
- Hepatopancreatoduodenectomy for Multifocal Cholangiocarcinoma in the Setting of Biliary Papillomatosis.Annals of surgical oncology · 2020Article
- Surgical Technique of Pancreatic Parenchyma Transection-Delayed Approach (PPTDA) in Hepatopancreatoduodenectomy for Hilar Cholangiocarcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Article
- A pooled analysis of en bloc right hemicolectomy with pancreaticoduodenectomy for locally advanced right-sided colon cancer.International journal of colorectal disease · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo review the evidence on the safety and efficacy of hepatopancreatoduodenectomy for biliary and gallbladder cancers.
methodsMedline and EMBASE were systematically searched for papers of hepatopancreatoduodenectomy in patients with biliary and gallbladder cancers.
resultsEighteen studies involving 397 patients were reviewed. Major hepatectomy was undertaken in 81.3% of the 397 patients and the R0 resection rate was 71.3%. The morbidity and mortality rates were 78.9% and 10.3%, respectively. The 5-year overall survival rate ranged from 3% to 50% (median = 31%). The 5-year survival rate in patients who underwent curative resection was 18-68.8% (median = 51.3%), and 0% in patients who received non-curative resection.
conclusionsHepatopancreatoduodenectomy is a challenging procedure with high morbidity and mortality rates. However, this procedure can provide a chance of long-term survival in patients in whom curative resection is feasible.
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Registered trials
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