ArticleLife sciences2016
Ovarian hormones modulate endothelin A and B receptor expression.
Article in Life sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
29 citing papers in PubMed, 35 citations in OpenAlex.
- Trial
- ETAmerican journal of physiology. Heart and circulatory physiology · 2021Trial
- Menopause and vascular endothelial health: Is it all about the oestrogen?Experimental physiology · 2026Review
- Progesterone signaling in cardio-renal physiology and pathophysiology.Frontiers in endocrinology · 2026Review
- Endothelin-1 signaling in the kidney: recent advances and remaining gaps.American journal of physiology. Renal physiology · 2025Review
- Short-term estradiol administration does not restore endothelin-B receptor-mediated vasodilation in postmenopausal women.American journal of physiology. Heart and circulatory physiology · 2025Article
- Maternal Microvascular Dysfunction During and After Preeclamptic Pregnancy.Comprehensive Physiology · 2024Review
- Endothelin receptor B is required for the blood pressure-lowering effect of G protein-coupled estrogen receptor 1 in ovariectomized rats.American journal of physiology. Renal physiology · 2024Article
- G protein-coupled estrogen receptor 1 regulates renal endothelin-1 signaling system in a sex-specific manner.Frontiers in physiology · 2023Article
- Acclimation to a High-Salt Diet Is Sex Dependent.Journal of the American Heart Association · 2022Article
- Endothelin-1 axes in the framework of predictive, preventive and personalised (3P) medicine.The EPMA journal · 2021Review
- Estradiol Regulates mRNA Levels of Estrogen Receptor Beta 4 and Beta 5 Isoforms and Modulates Human Granulosa Cell Apoptosis.International journal of molecular sciences · 2021Article
- Fever Induced by Zymosan A and Polyinosinic-Polycytidylic Acid in Female Rats: Influence of Sex Hormones and the Participation of Endothelin-1.Inflammation · 2021Article
- ET-1 as a Sex-Specific Mechanism Impacting Age-Related Changes in Vascular Function.Frontiers in aging · 2021Review
- Functional Interaction of Endothelin Receptors in Mediating Natriuresis Evoked by G Protein-Coupled Estrogen Receptor 1.The Journal of pharmacology and experimental therapeutics · 2021Article
- Altered endothelial ETAmerican journal of physiology. Heart and circulatory physiology · 2020Article
- Evidence for G-Protein-Coupled Estrogen Receptor as a Pronatriuretic Factor.Journal of the American Heart Association · 2020Article
- Sex differences in redox homeostasis in renal disease.Redox biology · 2020Review
- Immune-mediated febrile response in female rats: Role of central hypothalamic mediators.Scientific reports · 2020Article
- Greater natriuretic response to ENaC inhibition in male versus female Sprague-Dawley rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
aimsThe study aims to determine the modulatory roles of ovarian hormones, estrogen (E2) and progesterone (P), on the expression of endothelin A (ETA) and B (ETB) receptors in lung, liver and kidney tissues. MAIN
methodsFemale Sprague-Dawley rats were subjected to bilateral ovariectomy and divided into four groups ovariectomized (OVX), OVX+E2, OVX+P, and OVX+E2+P. A separate group of rats underwent sham surgery and served as a control. Three weeks after OVX or sham surgery, tissues from lungs, liver, renal cortex, and inner medulla were collected, snap-frozen, and kept at -80°C for assessment of ETA and ETB receptor expression using real-time PCR. KEY
findingsE2-treated OVX animals had significantly lower expression of ETA receptors in the lungs, compared to OVX rats. Pulmonary ETB receptor mRNA was not measurably affected by any of the interventions. Hepatic ETA and ETB were significantly increased in OVX+E2+P rats, compared to sham rats. Renal inner medullary ETA and ETB receptor expressions were significantly elevated in OVX compared to sham, an effect that was prevented by co-supplementation of OVX with E2 and P. Additionally, both ETA and ETB receptor expression in the renal cortex were significantly attenuated by ovariectomy, and this reduction was not evident in OVX+E2 rats. SIGNIFICANCE: These data suggest that ovarian hormones regulate ET receptor expression and may contribute to sex differences in cardiovascular and renal health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.