Evidence map›Paper›PMID 26776487›Full record

ReviewChemical Society reviews2016

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems.

Mahdi Karimi, Amir Ghasemi, Parham Sahandi Zangabad, Reza Rahighi, S Masoud Moosavi Basri, H Mirshekari, M Amiri, Z Shafaei Pishabad, A Aslani, M Bozorgomid and 7 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chemical Society reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 371 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
371citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

371 citing papers in PubMed, 1 synthesis or guideline pooled it.

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311 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mahdi KarimiDepartment of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Amir GhasemiDepartment of Materials Science and Engineering, Sharif University of Technology, 11365-9466, Tehran, Iran.
Parham Sahandi ZangabadDepartment of Materials Science and Engineering, Sharif University of Technology, 11365-9466, Tehran, Iran.
Reza RahighiDepartment of Research and Development, Sharif Ultrahigh Nanotechnologists (SUN) Company, P.O. Box: 13488-96394, Tehran, Iran and Nanotechnology Research Center, Research Institute of Petroleum Industry (RIPI), West Entrance Blvd., Olympic Village, P.O. Box: 14857-33111, Tehran, Iran.
S Masoud Moosavi BasriBioenvironmental Research Center, Sharif University of Technology, Tehran, Iran and Civil & Environmental Engineering Department, Shahid Beheshti University, Tehran, Iran.
H MirshekariDepartment of Biotechnology, University of Kerala, Trivandrum, India.
M AmiriDepartment of Materials Science and Engineering, Sharif University of Technology, 11365-9466, Tehran, Iran.
Z Shafaei PishabadDepartment of Cell & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
A AslaniDepartment of Materials Science and Engineering, Sharif University of Technology, 11365-9466, Tehran, Iran.
M BozorgomidDepartment of Applied Chemistry, Central Branch of Islamic Azad University of Tehran, Tehran, Iran.
D GhoshDepartment of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran.
A BeyzaviSchool of Mechanical Engineering, Boston University, Boston, MA, USA.
A VaseghiDepartment of Biotechnology, Faculty of Advanced Science and Technologies of Isfahan, Isfahan, Iran.
A R ArefDepartment of Cancer Biology, Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Department of Genetics, Harvard Medical School, Boston, MA 02215, USA.
L HaghaniSchool of Medicine, International Campus of Tehran University of Medical Science, Tehran, Iran.
S BahramiDepartment of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA. Hamblin@helix.mgh.harvard.edu and Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA and Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
NIAID NIH HHS R01 AI050875NIAID NIH HHS R01AI050875
6 · The paper itself

Abstract

New achievements in the realm of nanoscience and innovative techniques of nanomedicine have moved micro/nanoparticles (MNPs) to the point of becoming actually useful for practical applications in the near future. Various differences between the extracellular and intracellular environments of cancerous and normal cells and the particular characteristics of tumors such as physicochemical properties, neovasculature, elasticity, surface electrical charge, and pH have motivated the design and fabrication of inventive "smart" MNPs for stimulus-responsive controlled drug release. These novel MNPs can be tailored to be responsive to pH variations, redox potential, enzymatic activation, thermal gradients, magnetic fields, light, and ultrasound (US), or can even be responsive to dual or multi-combinations of different stimuli. This unparalleled capability has increased their importance as site-specific controlled drug delivery systems (DDSs) and has encouraged their rapid development in recent years. An in-depth understanding of the underlying mechanisms of these DDS approaches is expected to further contribute to this groundbreaking field of nanomedicine. Smart nanocarriers in the form of MNPs that can be triggered by internal or external stimulus are summarized and discussed in the present review, including pH-sensitive peptides and polymers, redox-responsive micelles and nanogels, thermo- or magnetic-responsive nanoparticles (NPs), mechanical- or electrical-responsive MNPs, light or ultrasound-sensitive particles, and multi-responsive MNPs including dual stimuli-sensitive nanosheets of graphene. This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.

Indexed as

Drug Delivery SystemsDNADrug CarriersHydrogen-Ion ConcentrationMicellesNanoparticlesPharmaceutical PreparationsDNADrug CarriersMicellesPharmaceutical Preparations

Identifiers

PMID26776487
PMCPMC4775468

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.