ReviewNature reviews. Endocrinology2016
The Framingham Heart Study--67 years of discovery in metabolic disease.
Review in Nature reviews. Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Transcriptome Profiling of Adipose Tissue Reveals Depot-Specific Metabolic Alterations Among Patients with Colorectal Cancer.The Journal of clinical endocrinology and metabolism · 2019Trial
- Directional drift in biologically meaningful vector planes: A proposed geometric framework for early detection of subthreshold disease.PloS one · 2026Article
- Observational
- Prevalence of diabetes and its correlates among Iranian adults: Results of the first phase of Shahedieh cohort study.Health science reports · 2023Article
- The changing landscape of drug clinical trials on cardiometabolic diseases in China, 2009-2021.Diabetology & metabolic syndrome · 2023Article
- Clustering of Small Territories Based on Axes of Inequality.International journal of environmental research and public health · 2022Article
- Validation of a Strict Obesity Definition Proposed for Asians to Predict Adverse Pregnancy Outcomes in Korean Pregnant Women.Journal of Korean medical science · 2021Article
- Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective.International journal of epidemiology · 2020Article
- Sickle cell disease in Africa: an urgent need for longitudinal cohort studies.The Lancet. Global health · 2019Article
- Camk2n1 Is a Negative Regulator of Blood Pressure, Left Ventricular Mass, Insulin Sensitivity, and Promotes Adiposity.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Gut microbiome and microbial metabolites: a new system affecting metabolic disorders.Journal of endocrinological investigation · 2019Review
- Article
- Luteolin Attenuates Cardiac Ischemia/Reperfusion Injury in Diabetic Rats by Modulating Nrf2 Antioxidative Function.Oxidative medicine and cellular longevity · 2019Article
- SUMMIT (Serially Unified Multicenter Multiple Sclerosis Investigation): creating a repository of deeply phenotyped contemporary multiple sclerosis cohorts.Multiple sclerosis (Houndmills, Basingstoke, England) · 2018Article
- Future of Treatment for Nonalcoholic Steatohepatitis: Can the Use of Safe, Evidence-Based, Clinically Proven Supplements Provide the Answer to the Unmet Need?Digestive diseases and sciences · 2018Review
- New perspectives: systems medicine in cardiovascular disease.BMC systems biology · 2018Article
- Monocyte gene expression in childhood obesity is associated with obesity and complexity of atherosclerosis in adults.Scientific reports · 2017Article
- Involvement of the metabolic sensor GPR81 in cardiovascular control.JCI insight · 2017Article
- Therapeutic opportunities for alcoholic steatohepatitis and nonalcoholic steatohepatitis: exploiting similarities and differences in pathogenesis.JCI insight · 2017Review
- Branched-chain amino acids differently modulate catabolic and anabolic states in mammals: a pharmacological point of view.British journal of pharmacology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The Framingham Heart Study (FHS), initiated in 1948, is the longest running prospective cohort study in the USA. Through >65 years of discovery, the FHS has contributed to our understanding of obesity, type 2 diabetes mellitus and prediabetes mellitus, the metabolic syndrome and nonalcoholic fatty liver disease (NAFLD), and to how these conditions relate to our overall and cardiovascular-related mortality. This Timeline gives an overview of the substantial role the FHS has played in advancing the understanding of obesity, diabetes mellitus and NAFLD, and considers the direction the FHS will take in the years to come.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.