Evidence map›Paper›PMID 26774871›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2016

Stroke Symptoms as a Predictor of Future Hospitalization.

Virginia J Howard, Monika M Safford, Shauntice Allen, Suzanne E Judd, J David Rhodes, Dawn O Kleindorfer, Elsayed Z Soliman, James F Meschia, George Howard

Abstract read
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Atrial Fibrillation and Stroke Symptoms in the REGARDS Study.Journal of the American Heart Association · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Virginia J HowardDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: vjhoward@uab.edu.
Monika M SaffordDivision of Preventive Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Shauntice AllenDean's Office, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.
Suzanne E JuddDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.
J David RhodesDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.
Dawn O KleindorferDepartment of Neurology, University of Cincinnati, Cincinnati, Ohio.
Elsayed Z SolimanDepartments of Epidemiology/Prevention and Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina.
James F MeschiaDepartment of Neurology, Mayo Clinic Florida, Jacksonville, Florida.
George HowardDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Understanding Cohort Effects on Stroke, VCID, and Cognition After Major Epidemiologic TransitionsRF1NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2024 to 2024
$16.2M
REGARDS - MI StudyR01HL080477 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2006 to 2020
$11.6M
Understanding Cohort Effects on Stroke, VCID, and Cognition After Major Epidemiologic TransitionsR01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MARY CUSHMAN, VIRGINIA J. HOWARD · 2001 to 2026
$8.8M
NHLBI NIH HHS R01 HL080477NINDS NIH HHS NS041588NINDS NIH HHS R01 NS041588NINDS NIH HHS RF1 NS041588NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

backgroundStroke symptoms in the general adult population are common and associated with stroke risk factors, lower physical and mental functioning, impaired cognitive status, and future stroke. Our objective was to determine the association of stroke symptoms with self-reported hospitalization or emergency department (ED) visit.

methodsLifetime history of stroke symptoms (sudden weakness, numbness, unilateral or general loss of vision, loss of ability to communicate or understand) was assessed at baseline in a national, population-based, longitudinal cohort study of 30,239 blacks and whites younger than 45 years, enrolled from 2003 to 2007. Self-reported hospitalization or ED visit and reason were collected during follow-up through March 2013. The symptom-hospitalization association was assessed by proportional hazards analysis in persons who were stroke/transient ischemic attack-free at baseline (27,126) with adjustment for sociodemographics and further adjustment for risk factors.

resultsOne or more stroke symptoms were reported by 4758 (17.5%). After adjustment for sociodemographics, stroke symptoms were most strongly associated with greater risk of hospitalization/ED for cardiovascular disease (CVD) (hazard ratio [HR] = 1.87, 95% confidence interval [CI]: 1.78-1.96), stroke (HR = 1.69, 95% CI: 1.55-1.85), and any reason (HR = 1.39, 95% CI: 1.34-1.44). These associations remained significant and only modestly reduced after risk factor adjustment.

conclusionsStroke symptoms are a marker for future hospitalization and ED visit not only for stroke but also for CVD in general. Findings suggest a role for stroke symptom assessment as a novel and simple approach for identifying individuals at high risk for CVD including stroke in whom preventive strategies could be implemented.

Indexed as

HospitalizationAdolescentAdultCohort StudiesFemaleHumansMaleOutcome Assessment, Health CarePredictive Value of TestsProportional Hazards ModelsRisk FactorsStrokeYoung Adultcardiovascular diseasehospitalizationprospective studiesstrokeStroke symptoms

Identifiers

PMID26774871
PMCPMC4779679

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.