ArticleRegulatory toxicology and pharmacology : RTP2016
Adverse outcome pathways: From research to regulation scientific workshop report.
Article in Regulatory toxicology and pharmacology : RTP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Mass Spectrometry Proteomics: A Key to Faster Drug Discovery.Journal of medicinal chemistry · 2026Review
- Artificial intelligence (AI)-it's the end of the tox as we know it (and I feel fine).Archives of toxicology · 2024Review
- Development of an adverse outcome pathway network for nephrotoxicity.Archives of toxicology · 2024Article
- A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target.The Science of the total environment · 2023Article
- Natural language processing in toxicology: Delineating adverse outcome pathways and guiding the application of new approach methodologies.Biomaterials and biosystems · 2022Article
- Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework.Journal of clinical medicine · 2022Review
- Impact of High-Throughput Model Parameterization and Data Uncertainty on Thyroid-Based Toxicological Estimates for Pesticide Chemicals.Environmental science & technology · 2022Article
- Development of a putative adverse outcome pathway network for male rat reproductive tract abnormalities with specific considerations for the androgen sensitive window of development.Current research in toxicology · 2021Article
- Progress in data interoperability to support computational toxicology and chemical safety evaluation.Toxicology and applied pharmacology · 2019Review
- When Are Adverse Outcome Pathways and Associated Assays "Fit for Purpose" for Regulatory Decision-Making and Management of Chemicals?Integrated environmental assessment and management · 2019Article
- Adverse Outcome Pathways: Moving from a Scientific Concept to an Internationally Accepted Framework.Environmental toxicology and chemistry · 2019Article
- Detection and analysis of endogenous polar volatile organic compounds (PVOCs) in urine for human exposome research.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2019Article
- Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers.Regulatory toxicology and pharmacology : RTP · 2019Article
- Advancing internal exposure and physiologically-based toxicokinetic modeling for 21st-century risk assessments.Journal of exposure science & environmental epidemiology · 2019Review
- Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA.Journal of exposure science & environmental epidemiology · 2018Review
- Representing the Process of Inflammation as Key Events in Adverse Outcome Pathways.Toxicological sciences : an official journal of the Society of Toxicology · 2018Review
- Differentiating Pathway-Specific From Nonspecific Effects in High-Throughput Toxicity Data: A Foundation for Prioritizing Adverse Outcome Pathway Development.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- In vitro to in vivo extrapolation for high throughput prioritization and decision making.Toxicology in vitro : an international journal published in association with BIBRA · 2018Review
- Immunotoxicology: A brief history, current status and strategies for future immunotoxicity assessment.Current opinion in toxicology · 2017Article
- Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
An adverse outcome pathway (AOP) helps to organize existing knowledge on chemical mode of action, starting with a molecular initiating event such as receptor binding, continuing through key events, and ending with an adverse outcome such as reproductive impairment. AOPs can help identify knowledge gaps where more research is needed to understand the underlying mechanisms, aid in chemical hazard characterization, and guide the development of new testing approaches that use fewer or no animals. A September 2014 workshop in Bethesda, Maryland considered how the AOP concept could improve regulatory assessments of chemical toxicity. Scientists from 21 countries, representing industry, academia, regulatory agencies, and special interest groups, attended the workshop, titled Adverse Outcome Pathways: From Research to Regulation. Workshop plenary presentations were followed by breakout sessions that considered regulatory acceptance of AOPs and AOP-based tools, criteria for building confidence in an AOP for regulatory use, and requirements to build quantitative AOPs and AOP networks. Discussions during the closing session emphasized a need to increase transparent and inclusive collaboration, especially with disciplines outside of toxicology. Additionally, to increase impact, working groups should be established to systematically prioritize and develop AOPs. Multiple collaborative projects and follow-up activities resulted from the workshop.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.