ReviewCurrent opinion in neurobiology2016
Multiple signals in anterior cingulate cortex.
Review in Current opinion in neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
126 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional brain changes in vascular cognitive impairment: a whole brain ALE meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Neural basis of compositional control.Nature · 2026Article
- Neural and computational mechanisms of effort under the pressure of a deadline.Nature communications · 2026Article
- Anterior cingulate cortex monitors action state and action content in complex associative learning.eLife · 2026Article
- Neural similarity between choice options predicts group-level context effects.Nature communications · 2026Article
- Computational origins of cortical brain circuits for social cognition.Nature reviews. Neuroscience · 2026Review
- Abnormal Resting-State Functional Connectivity Between the Dorsal Anterior Cingulate Cortex and the Limbic System Contributes to Pain and Emotion Regulation Impairment in Fibromyalgia Patients.International journal of rheumatic diseases · 2026Article
- Cadherin 11 regulates presynaptic vesicle trafficking and neuronal activity in autism-related brain circuit.Molecular psychiatry · 2026Article
- Neural representation of the decisional reference point in monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Complex functions of human lateral frontopolar cortex.Brain : a journal of neurology · 2025Review
- Marmoset Anterior Cingulate Area 32 Neurons Exhibit Responses to Presented and Produced Calls during Naturalistic Vocal Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Single-Neuron Encoding of Learnability in the Dorsal Anterior Cingulate Cortex.bioRxiv : the preprint server for biology · 2025Article
- Preparatory attentional templates in prefrontal and sensory cortex encode target-associated information.eLife · 2025Article
- The Trembling Hand Unraveled: Motor Dynamics and Choice Inconsistency.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Expectation violations signal goals in novel human communication.Nature communications · 2025Article
- Apathy and Impulsivity Co-Occur in Huntington's Disease.Brain and behavior · 2024Article
- Deconstruction the feedforward inhibition changes in the layer III of anterior cingulate cortex after peripheral nerve injury.Communications biology · 2024Article
- Generalized Encoding of the Relative Subjective Value of Cognitive Effort in the Dorsal ACC.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dissociable Representations of Decision Variables within Subdivisions of the Macaque Orbital and Ventrolateral Frontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Irrational choices via a curvilinear representational geometry for value.Nature communications · 2024Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Activity in anterior cingulate cortex (ACC) has been linked both to commitment to a course of action, even when it is associated with costs, and to exploring or searching for alternative courses of action. Here we review evidence that this is due to the presence of multiple signals in ACC reflecting the updating of beliefs and internal models of the environment and encoding aspects of choice value, including the average value of choices afforded by the environment ('search value'). We contrast this evidence with the influential view that ACC activity is better described as reflecting task difficulty. A consideration of cortical neural network properties explains why ACC may carry such signals and also exhibit sensitivity to task difficulty.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.