Evidence map›Paper›PMID 26774609›Full record

ArticleNeuroImage2016

Intrinsic connectivity of neural networks in the awake rabbit.

Matthew P Schroeder, Craig Weiss, Daniel Procissi, John F Disterhoft, Lei Wang

Open access · greenAbstract read
In one paragraph

Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Active neural coordination of motor behaviors with internal states.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  3. Diet-induced Alzheimer's-like syndrome in the rabbit.Alzheimer's & dementia (New York, N. Y.) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Matthew P SchroederDepartment of Physiology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Ward Building 7-140, Chicago, Illinois 60611, USA.
Craig WeissDepartment of Physiology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Ward Building 7-140, Chicago, Illinois 60611, USA.
Daniel ProcissiDepartment of Radiology, Feinberg School of Medicine, Northwestern University, 737 North Michigan Avenue, Suite 1600, Chicago, IL 60611, USA.
John F Disterhoft *Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Ward Building 7-140, Chicago, Illinois 60611, USA.
Lei Wang *Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 North Michigan Avenue, Suite 1600, Chicago, IL 60611, USA.
Northwestern University · US

Funding

TRAINING PROGRAM IN THE NEUROSCIENCE OF HUMAN COGNITIONT32NS047987 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Rodrigo M Braga, Christina Maria Zelano · 2006 to 2026
$5.6M
SYNAPTIC SUBSTRATES OF AGE-DEPENDENT MEMORY DEFICITSR01AG017139 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DISTERHOFT, JOHN F · 1999 to 2013
$4.6M
HIPPOCAMPAL SYSTEM FUNCTION ASSOCIATIVE LEARNINGR01MH047340 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DISTERHOFT, JOHN F · 1992 to 2012
$3.2M
The role of prefrontal cortex and thalamus during trace eyeblink conditioningR01NS059879 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WEISS, CRAIG · 2008 to 2011
$1.3M
Forebrain-Cerebellar Interaction During LearningR56MH047340 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DISTERHOFT, JOHN F · 2008 to 2008
$360k
NIA NIH HHS R01 AG017139NIMH NIH HHS R01 MH047340NIMH NIH HHS R56 MH047340NINDS NIH HHS R01 NS059879NINDS NIH HHS T32 NS047987NINDS NIH HHS T32-NS047987
6 · The paper itself

Abstract

The way in which the brain is functionally connected into different networks has emerged as an important research topic in order to understand normal neural processing and signaling. Since some experimental manipulations are difficult or unethical to perform in humans, animal models are better suited to investigate this topic. Rabbits are a species that can undergo MRI scanning in an awake and conscious state with minimal preparation and habituation. In this study, we characterized the intrinsic functional networks of the resting New Zealand White rabbit brain using BOLD fMRI data. Group independent component analysis revealed seven networks similar to those previously found in humans, non-human primates and/or rodents including the hippocampus, default mode, cerebellum, thalamus, and visual, somatosensory, and parietal cortices. For the first time, the intrinsic functional networks of the resting rabbit brain have been elucidated demonstrating the rabbit's applicability as a translational animal model. Without the confounding effects of anesthetics or sedatives, future experiments may employ rabbits to understand changes in neural connectivity and brain functioning as a result of experimental manipulation (e.g., temporary or permanent network disruption, learning-related changes, and drug administration).

Indexed as

Models, AnimalAnimalsBrainFemaleImage Processing, Computer-AssistedMagnetic Resonance ImagingNerve NetNeural PathwaysRabbitsWakefulnessAwake animal MRIDefault mode networkFunctional connectivityFunctional magnetic resonance imagingIndependent component analysis

Identifiers

PMID26774609
PMCPMC4803608
OpenAlexW2236795097

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.