Evidence map›Paper›PMID 26774404›Full record

Trial reportGrowth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society2016

FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth hormone.

Suman Srinivasa, Caroline Suresh, Jay Mottla, Sulaiman R Hamarneh, Javier E Irazoqui, Walter Frontera, Martin Torriani, Takara Stanley, Hideo Makimura

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Suman SrinivasaProgram in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: ssrinivasa@mgh.harvard.edu.
Caroline SureshProgram in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jay MottlaGeorgetown University, School of Medicine, Washington, DC, USA.
Sulaiman R HamarnehDepartment of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Javier E IrazoquiLaboratory of Comparative Immunology, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Walter FronteraDepartment of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Physical Medicine and Rehabilitation, Harvard Medical School/Spaulding Rehabilitation Hospital, Boston, MA, USA; Department of Physiology, University of Puerto Rico School of Medicine, Puerto Rico.
Martin TorrianiDivision of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Takara StanleyProgram in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Hideo MakimuraProgram in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Harvard University · USGeorgetown University · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, EMERY N · 1985 to 2008
$37.4M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
Role of MiT Transcription Factors in Host Defense Against Bacterial InfectionR01GM101056 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI IRAZOQUI, JAVIER ELBIO · 2012 to 2022
$3.9M
Growth Hormone, Mitochondria, and Cardio-metabolic Complications of ObesityK23DK087857 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MAKIMURA, HIDEO · 2010 to 2014
$796k
NCATS NIH HHS UL1 TR000170NCATS NIH HHS UL1 TR001102NCRR NIH HHS M01 RR001066NCRR NIH HHS UL1 RR025758NIDDK NIH HHS K23 DK087857NIDDK NIH HHS P30 DK040561NIGMS NIH HHS R01 GM101056
6 · The paper itself

Abstract

objectiveTo investigate the relationship of skeletal muscle FNDC5 mRNA expression and circulating irisin to the GH/IGF-I axis and to skeletal muscle mitochondrial function and mitochondria-related gene expression in obese men.

designFifteen abdominally obese men with reduced growth hormone received 12weeks of recombinant human GH (rhGH). Before and after treatment, they underwent (31)P-magnetic resonance spectroscopy to evaluate phosphocreatine (PCr) recovery as a measure of mitochondrial function and skeletal muscle biopsy to assess expression of mitochondrial-related genes. Serum irisin and IGF-I and skeletal muscle FNDC5 and IGF-I mRNA were measured.

resultsAt baseline, skeletal muscle FNDC5 mRNA was significantly and positively associated with IGF-I mRNA (ρ=0.81, P=0.005) and rate of PCr recovery (ρ=0.79, P=0.006). Similar relationships of circulating irisin to IGF-I mRNA (ρ=0.63, P=0.05) and rate of PCr recovery (ρ=0.48, P=0.08) were demonstrated, but were not as robust as those with muscle FNDC5 expression. Both serum irisin and skeletal muscle FNDC5 mRNA were significantly associated with PPARγ (ρ=0.73, P=0.02 and ρ=0.85, P=0.002), respectively. In addition, FNDC5 mRNA was correlated with skeletal muscle PGC-1α (ρ=0.68, P=0.03), NRF1 (ρ=0.66, P=0.04) and TFAM (ρ=0.79, P=0.007) mRNA. Neither serum irisin nor muscle mRNA expression of FNDC5 changed with rhGH treatment.

conclusionThese novel data in skeletal muscle demonstrate that local expression of FNDC5 is associated with mRNA expression of IGF-I and mitochondrial function and mitochondria-related gene expression in obese subjects with reduced growth hormone and suggest a potential role for FNDC5 acting locally in muscle in a low GH state. Further studies are needed to clarify the relationship between the GH/IGF-I axis and irisin.

Indexed as

AdolescentAdultFibronectinsGene ExpressionHuman Growth HormoneHumansHypopituitarismInsulin-Like Growth Factor IMaleMiddle AgedMitochondriaMuscle, SkeletalObesityYoung AdultFibronectinsFNDC5 protein, humanHuman Growth HormoneInsulin-Like Growth Factor IFNDC5Growth hormoneIGF-IIrisinMitochondrialObesitySkeletal muscle

Identifiers

PMID26774404
PMCPMC4716612
OpenAlexW2205007259

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.