Combination therapies for malaria are failing--what next?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

12 citing papers in PubMed.

1. Single dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission in Cambodia: An open-label randomized trial.PloS one · 2017
   Trial
2. Ex vivo piperaquine resistance developed rapidly in Plasmodium falciparum isolates in northern Cambodia compared to Thailand.Malaria journal · 2016
   Trial
3. An Assessment of Endothelial Markers in Patients with Uncomplicated Malaria in Jazan Province, Saudi Arabia.International journal of general medicine · 2025
   Article
4. GeneTargeter: AutomatedThe CRISPR journal · 2022
   Article
5. Purification and initial characterization of Plasmodium falciparum KMicrobial cell factories · 2020
   Article
6. Atovaquone-Proguanil in Combination With Artesunate to Treat Multidrug-ResistantOpen forum infectious diseases · 2019
   Article
7. Polyunsaturated fatty acids promoteBiology open · 2019
   Article
8. MIPhy: identify and quantify rapidly evolving members of large gene families.PeerJ · 2018
   Article
9. Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes.Cell · 2017
   Article
10. Partner-Drug Resistance and Population Substructuring of Artemisinin-Resistant Plasmodium falciparum in Cambodia.Genome biology and evolution · 2017
    Article
11. Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen.Nature communications · 2017
    Article
12. The Role of Eukaryotic and Prokaryotic ABC Transporter Family in Failure of Chemotherapy.Frontiers in pharmacology · 2016
    Review

Corrections and comments

• Comment on
  Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study.2016

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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