ArticlePhysiology & behavior2016
The ontogeny of ethanol aversion.
Article in Physiology & behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Age-related differences in the effect of chronic alcohol on cognition and the brain: a systematic review.Translational psychiatry · 2022Pooled it
- The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity-Related and Alcohol-Seeking Behaviors.CNS neuroscience & therapeutics · 2026Article
- Prenatal Exposure to Low Alcohol and Alcohol Motivation in the Offspring.Advances in experimental medicine and biology · 2026Review
- A translational rodent model of individual differences in sensitivity to the aversive properties of ethanol.Alcohol, clinical & experimental research · 2024Article
- Adolescent intermittent ethanol (AIE) produces lasting, sex-specific changes in rat body fat independent of changes in white blood cell composition.Frontiers in physiology · 2024Article
- A translational rodent model of individual differences in sensitivity to the aversive properties of ethanol.bioRxiv : the preprint server for biology · 2023Article
- Article
- Adolescent intermittent ethanol exposure does not alter responsiveness to ifenprodil or expression of vesicular GABA and glutamate transporters.Developmental psychobiology · 2021Article
- Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans.Brain sciences · 2020Review
- Excitatory/inhibitory balance across ontogeny contributes to age-specific behavioral outcomes of ethanol-like challenge in conditioned taste aversion.Developmental psychobiology · 2019Article
- Prenatal ethanol exposure attenuates sensitivity to the aversive effects of ethanol in adolescence and increases adult preference for a 5% ethanol solution in males, but not females.Alcohol (Fayetteville, N.Y.) · 2019Article
- Fos activation patterns related to acute ethanol and conditioned taste aversion in adolescent and adult rats.Alcohol (Fayetteville, N.Y.) · 2019Article
- Translational relevance of rodent models of hypothalamic-pituitary-adrenal function and stressors in adolescence.Neurobiology of stress · 2017Review
- Reward-centricity and attenuated aversions: An adolescent phenotype emerging from studies in laboratory animals.Neuroscience and biobehavioral reviews · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Recent work has suggested separate developmental periods within the broader framework of adolescence, with data suggesting distinct alterations and vulnerabilities within these intervals. While previous research has suggested reduced sensitivity to the aversive effects of alcohol in adolescence relative to adults, a more detailed ontogeny of this effect has yet to be conducted. The adolescent brain undergoes significant transitions throughout adolescence, including in regions linked with drug reward and aversion. The current study aimed to determine the ontogeny of ethanol aversion by utilizing a conditioned taste aversion procedure at six different ages to test the hypothesis that the transitions into, through, and out of adolescence are associated with ontogenetic alterations in sensitivity to the aversive properties of ethanol. Non-deprived animals given Boost® as the conditioned stimulus (CS) were used in Experiment 1, whereas Experiment 2 used water-restricted animals provided with a saccharin/sucrose solution as the CS. In both experiments, an attenuated sensitivity to the aversive properties of ethanol was evident in adolescents compared to adults, although more age differences were apparent in water deprived animals than when a highly palatable CS was given to ad libitum animals. Overall, the data suggest an attenuated sensitivity to the aversive properties of ethanol that is most pronounced during pre- and early adolescence, declining thereafter to reach the enhanced aversive sensitivity of adults.
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Registered trials
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