ArticleThe Journal of heredity2016
Cross-Species Application of SNP Chips is Not Suitable for Identifying Runs of Homozygosity.
Article in The Journal of heredity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Runs of Homozygosity and Inferences in Wild Populations.Molecular ecology · 2025Review
- Molecular Diversity of the Casein Gene Cluster in Bovidae: Insights from SNP Microarray Analysis.Animals : an open access journal from MDPI · 2024Article
- Demographic history and genomic signatures of selection in a widespread vertebrate ectotherm.Molecular ecology · 2024Article
- Heritability of Horn Size in Thinhorn Sheep.Frontiers in genetics · 2019Article
- Response to "Cross-Species Application of SNP Chips is Not Suitable for Identifying Runs of Homozygosity" by Shafer, Miller, and Kardos.The Journal of heredity · 2016Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Cross-species application of single-nucleotide polymorphism (SNP) chips is a valid, relatively cost-effective alternative to the high-throughput sequencing methods generally required to obtain a genome-wide sampling of polymorphisms. Kharzinova et al. (2015) examined the applicability of SNP chips developed in domestic bovids (cattle and sheep) to a semi-wild cervid (reindeer). The ancestors of bovids and cervids diverged between 20 and 30 million years ago (Hassanin and Douzery 2003; Bibi et al. 2013). Empirical work has shown that for a SNP chip developed in a bovid and applied to a cervid species, approximately 50% genotype success with 1% of the loci being polymorphic is expected (Miller et al. 2012). The genotyping of Kharzinova et al. (2015) follows this pattern; however, these data are not appropriate for identifying runs of homozygosity (ROH) and can be problematic for estimating linkage disequilibrium (LD) and we caution readers in this regard.
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