ArticleJournal of affective disorders2016
Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder.
Article in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Application of Graph Theory for Identifying Connectivity Patterns in Human Brain Networks: A Systematic Review.Frontiers in neuroscience · 2019Pooled it
- Psychoradiological patterns of small-world properties and a systematic review of connectome studies of patients with 6 major psychiatric disordersJournal of psychiatry & neuroscience : JPN · 2018Pooled it
- Sertraline Effects on Striatal Resting-State Functional Connectivity in Youth With Obsessive-Compulsive Disorder: A Pilot Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Trial
- Mechanisms of cognitive-behavioral therapy for obsessive-compulsive disorder involve robust and extensive increases in brain network connectivity.Translational psychiatry · 2017Trial
- Shared and distinct alterations of thalamic subregional functional connectivity in early- and late-onset obsessive-compulsive disorder.Psychological medicine · 2025Article
- Abnormal neural circuits and altered brain network topological properties in patients with chronic unilateral vestibulopathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- DSAM: A deep learning framework for analyzing temporal and spatial dynamics in brain networks.Medical image analysis · 2025Article
- Abnormal neural circuits and altered brain network topological properties in patients with persistent postural-perceptual dizziness.Communications biology · 2025Article
- Functional connectivity of the pediatric brain.Neuroradiology · 2024Review
- Graph Theory and Modeling of Network Topology in Clinical Neurosurgery.Advances in experimental medicine and biology · 2024Review
- Factors associated with psychological burden of breast cancer in women in Morocco: cross‑sectional study.BMC women's health · 2023Article
- Shared and Disorder-Specific Alterations of Brain Temporal Dynamics in Obsessive-Compulsive Disorder and Schizophrenia.Schizophrenia bulletin · 2023Article
- Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Identifying Replicable Subgroups in Neurodevelopmental Conditions Using Resting-State Functional Magnetic Resonance Imaging Data.JAMA network open · 2023Article
- The micro and macro interactions in acute autoimmune encephalitis: a study of resting-state EEG.Frontiers in neurology · 2023Article
- Altered brain functional network topology in Obsessive-Compulsive Disorder: A comparison of patients with varying severity of depressive symptoms and the impact on psychosocial functioning.NeuroImage. Clinical · 2023Article
- Preliminary Observations of Resting-State Magnetoencephalography in Nonmedicated Children with Obsessive-Compulsive Disorder.Journal of child and adolescent psychopharmacology · 2022Article
- Through the looking glass: Deep interpretable dynamic directed connectivity in resting fMRI.NeuroImage · 2022Article
- Obsessive-compulsive symptoms and resting-state functional characteristics in pre-adolescent children from the general population.Brain imaging and behavior · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundfMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD.
methodsWhole-brain resting-state fMRI was acquired at 3T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 child-based functional nodes. We also compared local metrics between groups in frontopolar, supplementary motor, and sensorimotor cortices, regions implicated in recent neuroimaging and/or brain stimulation treatment studies in OCD.
resultsAs in adults, the global metric small-worldness was significantly (P<0.05) lower in patients than controls, by 13.5% (%mean difference=100%X(OCD mean - control mean)/control mean). This suggests less efficient information transfer in patients. In addition, modularity was lower in OCD (15.1%, P<0.01), suggesting less granular - or differently organized - functional brain parcellation. Higher clustering coefficients (23.9-32.4%, P<0.05) were observed in patients in frontopolar, supplementary motor, sensorimotor, and cortices with lower betweenness centrality (-63.6%, P<0.01) at one frontopolar site. These findings are consistent with more locally intensive connectivity or less interaction with other brain regions at these sites. LIMITATIONS: Relatively large node size; relatively small sample size, comorbidities in some patients.
conclusionsPediatric OCD patients demonstrate aberrant global and local resting-state network connectivity topologies compared to healthy children. Local results accord with recent views of OCD as a disorder with sensorimotor component.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.