Evidence map›Paper›PMID 26773907›Full record

ArticleJournal of affective disorders2016

The temporal course and clinical correlates of subjective impulsivity in bipolar disorder as revealed through ecological momentary assessment.

Colin A Depp, Raeanne C Moore, Sheena I Dev, Brent T Mausbach, Lisa T Eyler, Eric L Granholm

Abstract read
In one paragraph

Article in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Colin A DeppUC San Diego Department of Psychiatry, La Jolla, CA, United States; VA San Diego, La Jolla, CA, United States. Electronic address: cdepp@ucsd.edu.
Raeanne C MooreUC San Diego Department of Psychiatry, La Jolla, CA, United States; VA San Diego, La Jolla, CA, United States.
Sheena I DevUC San Diego Department of Psychiatry, La Jolla, CA, United States; VA San Diego, La Jolla, CA, United States.
Brent T MausbachUC San Diego Department of Psychiatry, La Jolla, CA, United States.
Lisa T EylerUC San Diego Department of Psychiatry, La Jolla, CA, United States; VA San Diego, La Jolla, CA, United States.
Eric L GranholmUC San Diego Department of Psychiatry, La Jolla, CA, United States; VA San Diego, La Jolla, CA, United States.

Funding

FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
Dynamic Inflammatory and Mood Predictors of Cognitive Aging in Bipolar DisorderR01MH103318 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EYLER, LISA T · 2014 to 2018
$2.8M
Real-Time Mobile Cognitive Behavioral Intervention for Serious Mental IllnessR01MH100417 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2013 to 2016
$2.1M
Real-Time Mobile Assessment of Daily Functioning Among Older HIV-Infected AdultsK23MH107260 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MOORE, RAEANNE CRISTINE · 2015 to 2018
$927k
A Medication Adherence Intervention for Older Adults with Bipolar DisorderK23MH077225 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2007 to 2011
$763k
NIMH NIH HHS K23 MH077225NIMH NIH HHS K23 MH107260NIMH NIH HHS L30 MH104725NIMH NIH HHS MH077225NIMH NIH HHS MH100417NIMH NIH HHS MH103318NIMH NIH HHS MH107260NIMH NIH HHS R01 MH100417NIMH NIH HHS R01 MH103318NIMH NIH HHS T32 MH019934
6 · The paper itself

Abstract

backgroundImpulsivity is frequently linked with bipolar disorder and is associated with mania and negative outcomes. The temporal dynamics of subjective impulsivity are unclear, in particular whether impulsivity precedes or follows changes in positive or negative affect.

methodsA total of 41 outpatients with bipolar disorder (I or II) were provided with mobile devices for 11 weeks and completed twice-daily surveys about affective states and subjective impulsivity. We examined the association between aggregate subjective impulsivity with baseline global cognitive function, suicide risk ratings, and medication adherence, as well as concurrent and lagged associations with momentary positive and negative affect ratings.

resultsA total of 2902 ratings were available across study subjects. Higher aggregate mean ratings of impulsivity were associated with worse baseline global cognitive function, prior suicide attempts, and self-reported problems with medication adherence, as well as more severe manic (but not depressive) symptoms. Time-lagged models indicated that greater negative affect, but not positive affect, predicted subsequent increases in subjective impulsivity, which, in turn, predicted diminished positive affect. LIMITATIONS: Other measures of impulsivity with which to validate subjective ratings were unavailable and the sample was restricted to generally clinically stable outpatients.

conclusionsSubjective impulsivity as measured by daily monitoring was associated with worse cognitive function and self-rated medication adherence, and higher suicide risk ratings. Impulsivity may be a maladaptive strategy to regulate negative affect in bipolar disorder.

Indexed as

Impulsive BehaviorAdultBipolar DisorderCognitionFemaleHumansMaleMedication AdherenceMiddle AgedRisk FactorsSelf ReportSuicide, AttemptedSymptom AssessmentTime FactorsAssessmentBipolar disorderEmotionMobile healthTechnologyTime series analysis

Identifiers

PMID26773907
PMCPMC4915941

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.