Trial reportCancer2016
Anxiety, pain, and nausea during the treatment of standard-risk childhood acute lymphoblastic leukemia: A prospective, longitudinal study from the Children's Oncology Group.
Trial report in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Barriers and facilitators to physical activity participation for child, adolescent, and young adult cancer survivors: a systematic review.Journal of cancer survivorship : research and practice · 2024Pooled it
- New Technologies to Improve Pain, Anxiety and Depression in Children and Adolescents with Cancer: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- The gut microbiome, symptoms, and targeted interventions in children with cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Pooled it
- Preparing Children for Invasive Medical Cancer Treatment with "My Logbook": Preliminary Results of a Pilot Study.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025Trial
- A pilot study of the effect of a home-based multimodal symptom-management program in children and adolescents undergoing chemotherapy.Cancer reports (Hoboken, N.J.) · 2021Trial
- Quality of life in pediatric oncology patients, caregivers and siblings after psychosocial screening: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Trial
- Associations of Age, Gender, and Family Income with Quality of Life in Children With Advanced Cancer.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology NursesTrial
- Pediatric Education Discharge Support Strategies for Newly Diagnosed Children With Cancer.Cancer nursingTrial
- Pain Experiences During Early Treatment for Pediatric Acute Lymphoblastic Leukemia: A Qualitative Study.Psycho-oncology · 2026Article
- Caregivers' Perspectives on Changes in Family Life During B-ALL Therapy: A Qualitative Study From the Children's Oncology Group.Pediatric blood & cancer · 2025Article
- Feasibility, Acceptability, and Preliminary Efficacy of a Remotely-Delivered Health Coaching Intervention for Young and Middle-Aged Cancer Survivors: A Phase II Pilot Study.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025Article
- Integrative and Complementary Interventions Result in Significant Positive Effect Sizes in Quality of Life and Symptom Burden among Patients with Pediatric Cancer and Other Serious Illness.Research square · 2025Article
- Study of Complementary and Integrative Interventions in Pediatric Patients With Serious Illness.Journal of pain and symptom management · 2025Article
- Parental Voices on Virtual Reality in Pediatric Oncology: Experiences, Needs, and Pathways for Co-Design.Journal of multidisciplinary healthcare · 2025Article
- Biopsychosocial risk factors for pain in early phases of pediatric cancer treatment.Frontiers in psychology · 2025Article
- Acupressure intervention for children: A scoping review.Belitung nursing journal · 2025Review
- Acute Neurotoxicity in Children Treated for Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma: A 10-Year Single-Centre Experience.Children (Basel, Switzerland) · 2024Article
- Fear, coping and support- from the perspective of children aged 10-17-year old having acute lymphoblastic leukemia.International journal of qualitative studies on health and well-being · 2024Article
- Health-related quality of life and its determinant factors in Thai children with cancer: parents vs. children perspectives.BMC pediatrics · 2024Article
- Health-related quality of life in children with childhood acute myeloid leukemia in China: A five-year prospective study.Heliyon · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundThis prospective study describes the procedure-related anxiety, treatment-related anxiety, pain, and nausea experienced by children with standard-risk acute lymphoblastic leukemia (ALL) during the first year of treatment.
methodsThis study was undertaken at 31 Children's Oncology Group (COG) sites. Eligible children who were 2 to 9.99 years old were enrolled in a COG trial for patients with newly diagnosed standard-risk ALL from 2005 to 2009. Parents completed a demographic survey at the baseline and the Pediatric Quality of Life Inventory 3.0 Cancer Module (proxy version) and the General Functioning Scale of the Family Assessment Device 1, 6, and 12 months after the diagnosis. The association between patient-related (age, sex, ethnicity, and treatment), parent-related (marital status and education), and family-related factors (functioning, income, and size) and symptom scores was evaluated.
resultsThe mean scores for procedure-related anxiety, treatment-related anxiety, and pain improved during the first year of treatment (P < .0389). The mean nausea score was poorer 6 months after the diagnosis in comparison with the other assessments (P = .0085). A younger age at diagnosis was associated with significantly worse procedure-related anxiety (P = .004). An older age (P = .0002) and assignment to the intensified consolidation study arm (P = .02) were associated with significantly worse nausea.
conclusionsChildren with ALL experienced decreasing treatment-related anxiety, procedure-related anxiety, and pain during the first year of treatment. In comparison with scores at 1 and 12 months, nausea was worse 6 months after the diagnosis. Minimization of procedure-related anxiety in younger children and improved nausea control in older children and those receiving more intensified treatment should be prioritized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.