Evidence map›Paper›PMID 26773662›Full record

ArticleBiomaterials2016

Local delivery of a carbohydrate analog for reducing arthritic inflammation and rebuilding cartilage.

Chaekyu Kim, Ok Hee Jeon, Do Hun Kim, J Jeremy Chae, Lucas Shores, Nicholas Bernstein, Rahul Bhattacharya, Jeannine M Coburn, Kevin J Yarema, Jennifer H Elisseeff

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  3. Article
  4. Review
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  6. Review
  7. Article
  8. Wnt signaling: a promising target for osteoarthritis therapy.Cell communication and signaling : CCS · 2019
    Review
  9. Article
  10. [Effect of bone morphogenetic protein 7/poly (lactide-co-glycolide) microspheres on theZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chaekyu KimTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Ok Hee JeonTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Do Hun KimTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
J Jeremy ChaeTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Lucas ShoresTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Nicholas BernsteinTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Rahul BhattacharyaTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Jeannine M CoburnTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Kevin J YaremaTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Jennifer H ElisseeffTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA. Electronic address: jhe@jhu.edu.
Johns Hopkins University · US

Funding

Synthesis amd Mechanism of Polyglucosamine for Cartilage Tissue EngineeringR01AR054005 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ELISSEEFF, JENNIFER H, YAREMA, KEVIN J · 2006 to 2013
$2.5M
Engineering and Integration of Osteochondral TissueR01EB005517 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ELISSEEFF, JENNIFER H · 2005 to 2008
$1.1M
NIAMS NIH HHS R01 AR054005NIAMS NIH HHS R01AR054005NIBIB NIH HHS R01 EB005517
6 · The paper itself

Abstract

Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation. Because OA has a multifactorial nature and complex interrelationship of the individual elements of a whole joint, there is a need for comprehensive therapeutic approaches for cartilage tissue engineering, which simultaneously address multiple aspects of disease etiology. In this work, we investigated a multifunctional carbohydrate-based drug candidate, tri-butanoylated N-acetyl-D-galactosamine analog (3,4,6-O-Bu3GalNAc) that induced cartilage tissue production by human mesenchymal stem cells (hMSCs) and human OA chondrocytes by modulating Wnt/β-catenin signaling activity. The dual effects promoted chondrogenesis of human MSC and reduced inflammation of human OA chondrocytes in in vitro cultures. Translating these findings in vivo, we evaluated therapeutic effect of 3,4,6-O-Bu3GalNAc on the rat model of posttraumatic OA when delivered via local intra-articular sustained-release delivery using microparticles and found this method to be efficacious in preventing OA progression. These results show that 3,4,6-O-Bu3GalNAc, a disease modifying OA drug candidate, has promising therapeutic potential for articular cartilage repair.

Indexed as

Drug Delivery SystemsRegenerationAnimalsAnti-Inflammatory AgentsBiomarkersCartilage, ArticularCell DifferentiationChondrocytesChondrogenesisDisease Models, AnimalExtracellular MatrixGalactosamineHumansInflammationMaleOsteoarthritisAnti-Inflammatory AgentsBiomarkersGalactosamineCarbohydratesDisease-modifying OA drugDrug deliveryMesenchymal stem cellsOsteoarthritisTissue engineering

Identifiers

PMID26773662
PMCPMC8021327
OpenAlexW2204318686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.