ArticleEchocardiography (Mount Kisco, N.Y.)2016
Right Heart Involvement in Patients with Sarcoidosis.
Article in Echocardiography (Mount Kisco, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2020Guideline
- Diagnosis and Management of Patients with Cardiac Sarcoidosis by a Regional Specialist Service.Diseases (Basel, Switzerland) · 2026Article
- Cardiac Sarcoidosis: Pathophysiology and Diagnostic-Therapeutic Processes.Reviews in cardiovascular medicine · 2026Review
- Beyond the Biopsy: Imaging Frontiers in Cardiac Sarcoidosis.Cardiology research and practice · 2026Review
- Sarcoidosis Associated Pulmonary Hypertension.Biomedicines · 2024Review
- Right ventricular longitudinal strain on CMR predicts ventricular arrhythmias and mortality in cardiac sarcoidosis.American heart journal plus : cardiology research and practice · 2022Article
- WASOG statement on the diagnosis and management of sarcoidosis-associated pulmonary hypertension.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Value of echocardiography using knowledge-based reconstruction in determining right ventricular volumes in pulmonary sarcoidosis: comparison with cardiac magnetic resonance imaging.The international journal of cardiovascular imaging · 2022Article
- The Importance of Multimodality Imaging in the Diagnosis and Management of Patients with Infiltrative Cardiomyopathies: An Update.Diagnostics (Basel, Switzerland) · 2021Review
- Arrhythmias in Cardiac Sarcoidosis Bench to Bedside: A Case-Based Review.Circulation. Arrhythmia and electrophysiology · 2021Review
- Defining prognosis in sarcoidosis.Medicine · 2020Observational
- Right Ventricular Abnormalities on Cardiovascular Magnetic Resonance Imaging in Patients With Sarcoidosis.JACC. Cardiovascular imaging · 2020Article
- Cardiac Sarcoidosis: Remembering the Forgotten Right Ventricle.JACC. Cardiovascular imaging · 2020Article
- Recommendations forJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Review
- The frequency of diastolic dysfunction in patients with sarcoidosis and it's relationship with HLA DRB1* alleles.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2019Article
- Echocardiography in Sarcoidosis.Current cardiology reports · 2018Review
- Sarcoidosis-associated Pulmonary Hypertension: Pathophysiology, Diagnosis, and Treatment.Clinical pulmonary medicine · 2018Article
- A joint procedural position statement on imaging in cardiac sarcoidosis: from the Cardiovascular and Inflammation & Infection Committees of the European Association of Nuclear Medicine, the European Association of Cardiovascular Imaging, and the American Society of Nuclear Cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Pulmonary hypertension complicating pulmonary sarcoidosis.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The left ventricle (LV) is affected in 20-25% of patients with sarcoidosis and its involvement is associated with morbidity and mortality. However, effects of sarcoidosis on the right ventricle (RV) are not well documented. Our aims were to investigate the prevalence of RV dysfunction in patients with sarcoidosis and determine whether it is predominantly associated with direct cardiac involvement, severity of lung disease, or pulmonary hypertension (PH). We identified 50 patients with biopsy-proven extra-cardiac sarcoidosis and preserved LV function, who underwent echocardiography, pulmonary function (PF) testing, and cardiovascular magnetic resonance. RV function was quantified by free wall longitudinal strain. Tricuspid valve Doppler and estimated right atrial pressure were used to estimate systolic pulmonary artery pressure. Myocardial late gadolinium enhancement was considered diagnostic for cardiac sarcoidosis and assumed to involve both ventricles. Of the 50 patients, 28 (56%) had RV dysfunction, 4 with poorly defined PF status. Of the remaining 24 patients, 16 (67%) had lung disease, 8 (33%) had PH, and 10 (42%) had LV involvement. Ten patients had greater than one of these findings, and 4 had all 3. In contrast, in 4/24 patients (17%), RV dysfunction could not be explained by these mechanisms, despite severely reduced RV strain. In conclusion, RV dysfunction is common in patients with sarcoidosis and is usually associated with either direct LV involvement, lung disease, or PH, but may occur in the absence of these mechanisms, suggesting the possibility of isolated RV involvement and underscoring the need for imaging protocols that would include RV strain analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.