ArticleBosnian journal of basic medical sciences2016
Fecal calprotectin is associated with disease activity in patients with ankylosing spondylitis.
Article in Bosnian journal of basic medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- The gut-bone axis in ankylosing spondylitis: mechanistic insights and the translational gap.Clinical and experimental medicine · 2025Review
- Gut inflammation is associated with structural spinal damage in axial spondyloarthritis - results from the observational SPARTAKUS cohort.Arthritis research & therapy · 2025Observational
- Gut microbiota and ankylosing spondylitis: current insights and future challenges.Microbial cell (Graz, Austria) · 2025Review
- GIScaSpA-study of subclinical gut involvement in axial spondyloarthritis.Rheumatology advances in practice · 2024Article
- Elevated type-17 cytokines are present in axial spondyloarthritis stool.Discovery immunology · 2024Article
- Fecal calprotectin in cirrhosis-Does "ESR" of the intestine measure the liver dysfunction too?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Article
- Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis.International journal of molecular sciences · 2022Review
- Selective estrogen receptor modulator lasofoxifene suppresses spondyloarthritis manifestation and affects characteristics of gut microbiota in zymosan-induced SKG mice.Scientific reports · 2021Article
- Dynamic changes in gut microbiota under the influence of smoking and TNF-α-blocker in patients with ankylosing spondylitis.Clinical rheumatology · 2020Article
- Biomarker development for axial spondyloarthritis.Nature reviews. Rheumatology · 2020Review
- An update on serum biomarkers to assess axial spondyloarthritis and to guide treatment decision.Therapeutic advances in musculoskeletal disease · 2020Review
- Biomarkers in Inflammatory Bowel Disease-Associated Spondyloarthritis: State of the Art and Unmet Needs.Journal of immunology research · 2019Review
- Association of circulating calprotectin with lipid profile in axial spondyloarthritis.Scientific reports · 2018Article
- Recent advances in ankylosing spondylitis: understanding the disease and management.F1000Research · 2018Review
- Dissecting the Underlying Pharmaceutical Mechanism of Chinese Traditional Medicine Yun-Pi-Yi-Shen-Tong-Du-Tang Acting on Ankylosing Spondylitis through Systems Biology Approaches.Scientific reports · 2017Article
- Calprotectin in rheumatic diseases.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- A longitudinal study of fecal calprotectin and the development of inflammatory bowel disease in ankylosing spondylitis.Arthritis research & therapy · 2017Observational
- Elevated levels of serum MRP8/14 in ankylosing spondylitis: associated with peripheral arthritis and active disease.Clinical rheumatology · 2016Article
- The Role of Fecal Calprotectin in Evaluating Intestinal Involvement of Behçet's Disease.Disease markers · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calprotectin is one of the major antimicrobial S100 leucocyte proteins. Serum calprotectin levels are associated with certain inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease. The aim of this study was to investigate serum and fecal calprotectin levels in patients with ankylosing spondylitis (AS) and show their potential relations to the clinical findings of the disease. Fifty-one patients fulfilling the New York criteria of AS and 43 healthy age- and gender-matched volunteers were included in the study. Physical and locomotor system examinations were performed and history data were obtained for all patients. Disease activity parameters were assessed together with anthropometric parameters. Routine laboratory examinations and genetic testing (HLA-B27) were performed. Serum calprotectin levels and fecal calprotectin levels were measured by an enzyme-linked immunosorbent assay. The mean age of the patients was 41.5 years, the mean duration of the disease was 8.6 years, and the delay in diagnosis was 4.2 years. Serum calprotectin levels were similar in both AS patients and in the control group (p=0.233). Serum calprotectin level was correlated with Bath AS disease activity index (BASDAI) and Bath AS functional index (BASFI) (p=0.001, p=0.002, respectively). A higher level of fecal calprotectin was detected in AS patients when compared with the control group. A statistically significant correlation between fecal calprotectin level and BASDAI, BASFI, C-reactive protein and Erythrocyte sedimentation rate were detected (p=0.002, p=0.005, p=0.001, p=0.002, respectively). The results indicated that fecal calprotectin levels were associated with AS disease findings and activity parameters. Calprotectin is a vital disease activity biomarker for AS and may have an important role in the pathogenesis of the disease. Multi-centered prospective studies are needed in order to provide further insight.
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