ArticleApplied and environmental microbiology2016
Genome Analysis of the Fruiting Body-Forming Myxobacterium Chondromyces crocatus Reveals High Potential for Natural Product Biosynthesis.
Article in Applied and environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
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- Harnessing Gram-negative bacteria for novel anti-Gram-negative antibiotics.Microbial biotechnology · 2024Review
- Phylogenetic Revisit to a Review on Predatory Bacteria.Microorganisms · 2023Review
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- Analysis of the Genome and Metabolome of Marine Myxobacteria Reveals High Potential for Biosynthesis of Novel Specialized Metabolites.Scientific reports · 2018Article
- In silico characterization of a novel putative aerotaxis chemosensory system in the myxobacterium, Corallococcus coralloides.BMC genomics · 2018Article
- Streptopeptolin, a Cyanopeptolin-Type Peptide fromACS omega · 2018Article
- Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria.Chemical science · 2018Article
- Screening for inhibitors of mutacin synthesis in Streptococcus mutans using fluorescent reporter strains.BMC microbiology · 2018Article
- Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria.Nature communications · 2018Article
- Diversity and Evolution of Myxobacterial Type IV Pilus Systems.Frontiers in microbiology · 2018Article
- Complete Genome Sequence of the Fruiting MyxobacteriumGenome announcements · 2017Article
- Draft Genome Sequence of the Fruiting MyxobacteriumGenome announcements · 2017Article
- Whole-Genome Sequence of the Fruiting MyxobacteriumGenome announcements · 2017Article
- Complete Genome Sequence of the Fruiting MyxobacteriumGenome announcements · 2017Article
- Screening and identification of novel biologically active natural compounds.F1000Research · 2017Review
- Analysis of bacterial communities and characterization of antimicrobial strains from cave microbiota.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here, we report the complete genome sequence of the type strain of the myxobacterial genus Chondromyces, Chondromyces crocatus Cm c5. It presents one of the largest prokaryotic genomes featuring a single circular chromosome and no plasmids. Analysis revealed an enlarged set of tRNA genes, along with reduced pressure on preferred codon usage compared to that of other bacterial genomes. The large coding capacity and the plethora of encoded secondary metabolite biosynthetic gene clusters are in line with the capability of Cm c5 to produce an arsenal of antibacterial, antifungal, and cytotoxic compounds. Known pathways of the ajudazol, chondramide, chondrochloren, crocacin, crocapeptin, and thuggacin compound families are complemented by many more natural compound biosynthetic gene clusters in the chromosome. Whole-genome comparison of the fruiting-body-forming type strain (Cm c5, DSM 14714) to an accustomed laboratory strain which has lost this ability (nonfruiting phenotype, Cm c5 fr-) revealed genetic changes in three loci. In addition to the low synteny found with the closest sequenced representative of the same family, Sorangium cellulosum, extensive genetic information duplication and broad application of eukaryotic-type signal transduction systems are hallmarks of this 11.3-Mbp prokaryotic genome.
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