ArticleNucleic acids research2016
Integration of multi-omics data of a genome-reduced bacterium: Prevalence of post-transcriptional regulation and its correlation with protein abundances.
Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Bacterial stress responses lower mRNA-protein level correlations.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The cell with many faces: lung macrophage plasticity and function in response to environmental and pathogenic insults.Physiological reviews · 2026Review
- Quantitative essentiality in a reduced genome: a functional, regulatory and structural fitness map.Molecular systems biology · 2025Article
- Article
- De novo gene birth and the conundrum of ORFan genes in bacteria.Genome research · 2025Review
- Towards improved biofilm models.Nature reviews. Microbiology · 2025Review
- Genomic analysis of prophages in 44 clinical strains ofFrontiers in cellular and infection microbiology · 2025Article
- Survival strategies of mycoplasmas: the critical role of post-translational modifications.Frontiers in cellular and infection microbiology · 2025Review
- Acetylomics reveals an extensive acetylation diversity withinmicroLife · 2024Article
- Development of a Serum-Free Medium To Aid Large-Scale Production ofMicrobiology spectrum · 2023Article
- Article
- A Practical Guide to Small Protein Discovery and Characterization Using Mass Spectrometry.Journal of bacteriology · 2022Article
- Factors affecting the rapid changes of protein under short-term heat stress.BMC genomics · 2021Article
- The Two TpsB-Like Proteins inJournal of bacteriology · 2021Article
- Protein quality control and regulated proteolysis in the genome-reduced organism Mycoplasma pneumoniae.Molecular systems biology · 2020Article
- Determinants of translation efficiency in the evolutionarily-divergent protist Trichomonas vaginalis.BMC molecular and cell biology · 2020Article
- Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent.Acta pharmaceutica Sinica. B · 2020Article
- Proteomic Applications in Antimicrobial Resistance and Clinical Microbiology Studies.Infection and drug resistance · 2020Review
- Prokaryotic Genome Expansion Is Facilitated by Phages and Plasmids but Impaired by CRISPR.Frontiers in microbiology · 2019Article
- Article
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Authors and funding
14 authors.
Funding
Abstract
We developed a comprehensive resource for the genome-reduced bacterium Mycoplasma pneumoniae comprising 1748 consistently generated '-omics' data sets, and used it to quantify the power of antisense non-coding RNAs (ncRNAs), lysine acetylation, and protein phosphorylation in predicting protein abundance (11%, 24% and 8%, respectively). These factors taken together are four times more predictive of the proteome abundance than of mRNA abundance. In bacteria, post-translational modifications (PTMs) and ncRNA transcription were both found to increase with decreasing genomic GC-content and genome size. Thus, the evolutionary forces constraining genome size and GC-content modify the relative contributions of the different regulatory layers to proteome homeostasis, and impact more genomic and genetic features than previously appreciated. Indeed, these scaling principles will enable us to develop more informed approaches when engineering minimal synthetic genomes.
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