ReviewThe journal of allergy and clinical immunology. In practice
Severe Asthma in Children: Lessons Learned and Future Directions.
Review in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 77 citations in OpenAlex.
- Rhinovirus as a driver of airway T cell dynamics in children with treatment-refractory recurrent wheeze.JCI insight · 2025Article
- Metabolomics Applied to Pediatric Asthma: What Have We Learnt in the Past 10 Years?Children (Basel, Switzerland) · 2023Article
- EoE behaves as a unique Th2 disease: a narrative review.Translational gastroenterology and hepatology · 2023Review
- Severe asthma in children: An official statement from Saudi Pediatric Pulmonology Association.Saudi medical journal · 2022Article
- Expression of LINC00847 in Peripheral Blood Mononuclear Cells of Children with Asthma and Its Prediction between Asthma Exacerbation and Remission.Genetics research · 2022Article
- The Role of Dupilumab in Severe Asthma.Biomedicines · 2021Review
- Biological Therapies in Children and Adolescents with Severe Uncontrolled Asthma: A Practical Review.Biologics : targets & therapy · 2021Review
- Biologics to Treat Severe Asthma in Children and Adolescents: A Practical Update.Pediatric allergy, immunology, and pulmonology · 2020Review
- An approach to the management of children with problematic severe asthma.Acta bio-medica : Atenei Parmensis · 2020Review
- How can we minimise the use of regular oral corticosteroids in asthma?European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Integrative study of the upper and lower airway microbiome and transcriptome in asthma.JCI insight · 2020Article
- Targeted Therapy for Severe Asthma in Children and Adolescents: Current and Future Perspectives.Paediatric drugs · 2019Article
- Epidemiology of Asthma in Children and Adults.Frontiers in pediatrics · 2019Review
- Inflammatory and Comorbid Features of Children Admitted to a PICU for Status Asthmaticus.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018Article
- Severe Asthma: Challenges and Pitfalls in Management.Indian journal of pediatrics · 2018Review
- Translating Asthma: Dissecting the Role of Metabolomics, Genomics and Personalized Medicine.Indian journal of pediatrics · 2018Article
- Measuring Airway Obstruction in Severe Asthma in Children.Frontiers in pediatrics · 2018Review
- Biomarkers in asthma: state of the art.Asthma research and practice · 2018Review
- Advances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology.Italian journal of pediatrics · 2017Review
- Severe Asthma in Children.Current allergy and asthma reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Severe asthma in children is a complicated and heterogeneous disorder that is extremely challenging to treat. Although most children with asthma derive clinical benefit from daily administration of low-to-medium-dose inhaled corticosteroid (ICS) therapy, a small subset of children with "severe" or "refractory" asthma require high doses of ICS and even systemic corticosteroids to maintain symptom control. These children with severe asthma are at increased risk for adverse outcomes including medication-related side effects and recurrent and life-threatening exacerbations that significantly impair quality of life. This review highlights findings on severe asthma in school-age children (age 6-17 years) from the National Heart, Lung and Blood Institute's Severe Asthma Research Program (SARP) over a 10-year period, between 2001 and 2011. Although SARP has advanced knowledge of the unique clinical, biological, and molecular attributes of severe asthma in children, considerable gaps remain for which additional studies are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.