ReviewThe journal of allergy and clinical immunology. In practice
Management of Preschool Children with Recurrent Wheezing: Lessons from the NHLBI's Asthma Research Networks.
Review in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Correlation Meta-Analysis of the Efficacy of Inhaled Corticosteroids in Children with Asthma Based on Smart Medical Health.Journal of healthcare engineering · 2022Pooled it
- Efficacy of three different budesonide treatments in Chinese preschool children with recurrent wheezing.Scientific reports · 2022Trial
- Bacterial Mucosal Immunotherapy with MV130 Prevents Recurrent Wheezing in Children: A Randomized, Double-Blind, Placebo-controlled Clinical Trial.American journal of respiratory and critical care medicine · 2021Trial
- Letter to the Editor: 100-day window: Reframing early follow-up and parental guidance in recurrent wheezing.World journal of clinical pediatrics · 2026Article
- Linking Gastroesophageal Reflux Characteristics to Airway Inflammation: Insights from Bronchoalveolar Lavage Cytology in Severe Preschool Wheeze.Life (Basel, Switzerland) · 2025Article
- Innate Immune Training for Prevention of Recurrent Wheeze in Early Childhood.American journal of respiratory and critical care medicine · 2021Article
- Respiratory Viral and Bacterial Factors That Influence Early Childhood Asthma.Frontiers in allergy · 2021Review
- Childhood asthma heterogeneity at the era of precision medicine: Modulating the immune response or the microbiota for the management of asthma attack.Biochemical pharmacology · 2020Review
- Key paediatric messages from the 2017 European Respiratory Society International Congress.ERJ open research · 2018Review
- Matched cohort study of therapeutic strategies to prevent preschool wheezing/asthma attacks.Journal of asthma and allergy · 2018Article
- Association of Asthma and Allergic Rhinitis With Sleep-Disordered Breathing in Childhood.Frontiers in pediatrics · 2018Article
- Asthma phenotypes: the intriguing selective intervention with Montelukast.Asthma research and practice · 2016Review
- Asthma in Childhood: Expression, Exacerbation, and Progression.The journal of allergy and clinical immunology. In practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recurrent wheezing in the preschool children is a common clinical problem, often associated with significant morbidity related to acute episodes. The management of these children has been complicated by a paucity of high-quality clinical trials in this age group. To fill this knowledge gap, National Heart, Lung, and Blood Institute's asthma research networks have performed a series of clinical trials in an effort to provide practitioners with guidance on appropriate management strategies. These studies establish daily inhaled corticosteroid (ICS) therapy in toddlers at high risk for subsequent asthma as an effective approach for the prevention of exacerbations and symptom reduction, but without evidence of disease-modifying properties. Additional studies have confirmed substantial heterogeneity in ICS response, in terms of both efficacy and effect on linear growth. Treatment with intermittent high-dose ICS was demonstrated to be an alternative approach to daily low-dose ICS for preventing severe exacerbations in toddlers with intermittent but significant wheeze and a positive modified asthma predictive index. This review details the findings and clinical implications derived from these studies, discuss the utility of biomarkers and the role of oral corticosteroids during acute exacerbations, and summarizes ongoing clinical trials in this age group.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.