ArticleUrology2016
Endoscopic and Pathologic Characterization of Papillary Architecture in Struvite Stone Formers.
Article in Urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Novel insights into the role of the renal interstitial microenvironment in Randall's plaque formation (Review).International journal of molecular medicine · 2026Review
- Renal papillary tip biopsy in stone formers: a review of clinical safety and insights.Urolithiasis · 2024Review
- Endoscopic Papillary Abnormalities and Stone Recognition (EPSR) during Flexible Ureteroscopy: A Comprehensive Review.Journal of clinical medicine · 2021Review
- Animal models of naturally occurring stone disease.Nature reviews. Urology · 2020Review
- Discrepancy Between Stone and Tissue Mineral Type in Patients with Idiopathic Uric Acid Stones.Journal of endourology · 2020Article
- Endoscopic observations as a tool to define underlying pathology in kidney stone formers.World journal of urology · 2019Article
- Current insights into the mechanisms and management of infection stones.Nature reviews. Urology · 2019Review
- Diagnosis and management of non-calcium-containing stones in the pediatric population.International urology and nephrology · 2018Review
- Integration and utilization of modern technologies in nephrolithiasis research.Nature reviews. Urology · 2016Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo describe the endoscopic characteristics of renal papillae in struvite stone formers (SFs). MATERIALS AND
methodsFrom 2009 to 2014, patients undergoing percutaneous nephrolithotomy were prospectively enrolled in our study. Endoscopic analysis and biopsy of papillae were performed to demonstrate the presence and percentage surface area (SA) of Randall's plaque or ductal plug. Comparison with idiopathic calcium oxalate (CaOx) SF and non-SF controls was performed.
resultsWe identified 29 struvite SFs to compare with 90 idiopathic CaOx SFs and 17 controls. On endoscopic mapping, 28 struvite SFs (97%) demonstrated Randall's plaque and 9 (31%) had plugging. The average mean SA of Randall's plaque in struvite SF (1.5 ± 1.4%) was less than CaOx SFs (3.7 ± 4.3%, P = .0018) and similar to controls (1.7 ± 2.7%, P = .76). Average mean plug SA was similar between struvite SFs, CaOx SFs, and controls. On metabolic assessment, 83% of struvite SFs had at least one urine abnormality, with urinary uric acid and oxalate levels significantly higher among struvite SFs compared to controls (P = .002). Despite lack of active urinary tract infection, interstitial inflammation was more prevalent in struvite SFs compared to CaOx SFs (43.5% vs 7.3%, P = .0001).
conclusionsOur findings suggest a limited role for Randall's plaque in struvite stone formation. Struvite SFs have less plaque formation than CaOx SFs, but demonstrate evidence of severe parenchymal inflammation compared to other SFs. The role of this prominent interstitial inflammation requires further study.
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