ReviewBiological psychiatry2016
Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders.
Review in Biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04946851 (Addictions Neuroclinical Assessment), which is not on this map. Cited by 226 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Addictions Neuroclinical Assessment
Who cites it
226 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Functional magnetic response imaging predictors of alcohol use disorder treatment outcome: a systematic review.Alcohol and alcoholism (Oxford, Oxfordshire) · 2026Pooled it
- Effects of Alcohol on EEG Activity: A Systematic Review Focused on Sex-Related Differences in Youth.Current neuropharmacology · 2025Pooled it
- The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.Journal of psychopathology and clinical science · 2024Pooled it
- Neuroscience-informed classification of prevention interventions in substance use disorders: An RDoC-based approach.Neuroscience and biobehavioral reviews · 2024Pooled it
- A systematic review of treatment for impulsivity and compulsivity.Frontiers in psychiatry · 2024Pooled it
- Cognitive training and remediation interventions for substance use disorders: a Delphi consensus study.Addiction (Abingdon, England) · 2023Pooled it
- The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews.Psychological bulletin · 2021Pooled it
- Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics.Neuroscience and biobehavioral reviews · 2021Pooled it
- Measurement of substance-free reinforcement in addiction: A systematic review.Clinical psychology review · 2019Pooled it
- A randomized controlled trial to assess whether a telehealth-based contingency management intervention reduces alcohol use for individuals with alcohol use disorder.Contemporary clinical trials · 2025Trial
- Psilocybin-induced changes in neural reactivity to alcohol and emotional cues in patients with alcohol use disorder: an fMRI pilot study.Scientific reports · 2024Trial
- Genetically influenced externalizing and internalizing risk pathways as novel prevention targets.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Trial
- Insomnia treatment effects among young adult drinkers: Secondary outcomes of a randomized pilot trial.Alcoholism, clinical and experimental research · 2021Trial
- Review
- Heterogeneous structural brain signatures of methamphetamine and ketamine use disorders revealed by normative modeling.Molecular psychiatry · 2026Article
- Relationship between depression on cocaine craving over time amongst patients in a trial evaluating the use of buprenorphine on cocaine use.Drug and alcohol dependence reports · 2026Article
- Cannabidiol and Alcohol Use Disorders: An Updated Review of Therapeutic Potential.Alcohol, clinical & experimental research · 2026Review
- Classification of Alcohol Use Disorder With Explainable AI.Alcohol, clinical & experimental research · 2026Article
- Pharmacological Inhibition of HDAC6 Transiently Reduces Voluntary Ethanol Consumption in Male Mice.Alcohol, clinical & experimental research · 2026Article
- Diagnostic validity of Addictions Neuroclinical Assessment indices for alcohol use disorder: Findings from an observational case-control study.Addiction (Abingdon, England) · 2026Observational
166 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
Authors and funding
5 authors.
Funding
Abstract
This article proposes a heuristic framework for the Addictions Neuroclinical Assessment that incorporates key functional domains derived from the neurocircuitry of addiction. We review how addictive disorders (ADs) are presently diagnosed and the need for new neuroclinical measures to differentiate patients who meet clinical criteria for addiction to the same agent while differing in etiology, prognosis, and treatment response. The need for a better understanding of the mechanisms provoking and maintaining addiction, as evidenced by the limitations of current treatments and within-diagnosis clinical heterogeneity, is articulated. In addition, recent changes in the nosology of ADs, challenges to current classification systems, and prior attempts to subtype individuals with ADs are described. Complementary initiatives, including the Research Domain Criteria project, that have established frameworks for the neuroscience of psychiatric disorders are discussed. Three domains-executive function, incentive salience, and negative emotionality-tied to different phases in the cycle of addiction form the core functional elements of ADs. Measurement of these domains in epidemiologic, genetic, clinical, and treatment studies will provide the underpinnings for an understanding of cross-population and temporal variation in addictions, shared mechanisms in addictive disorders, impact of changing environmental influences, and gene identification. Finally, we show that it is practical to implement such a deep neuroclinical assessment using a combination of neuroimaging and performance measures. Neuroclinical assessment is key to reconceptualizing the nosology of ADs on the basis of process and etiology, an advance that can lead to improved prevention and treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.