ArticleHuman pathology2016
Pediatric cystic nephromas: distinctive features and frequent DICER1 mutations.
Article in Human pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol.Nature reviews. Urology · 2018Guideline
- "A dicey situation:" asymptomatic hypertensive urgency caused by DICER1 mutation-derived cystic nephroma in a 12-month-old.Pediatric nephrology (Berlin, Germany) · 2026Article
- Article
- Cystic wilms tumor, cystic partially differentiated nephroblastoma, or cystic nephroma? A case report and review of the literature.Urology case reports · 2025Article
- Massive Cystic Nephroma in a 13-Month-Old Girl: Case Report and Differential Diagnostic Outcome.Turkish archives of pediatrics · 2025Article
- Data set for reporting paediatric renal tumours: recommendations from the international collaboration on cancer reporting (ICCR).Histopathology · 2025Review
- Paediatric renal tumors: An insight into molecular characteristics, histomorphology and syndromic association.World journal of nephrology · 2025Review
- Neonatal Supraventricular Tachycardia- The Bedside Ultrasound Unearths Hidden Bullets.Indian journal of pediatrics · 2025Article
- Expanding Our Knowledge ofCancers · 2024Review
- Mixed Epithelial and Stromal Tumor: A Rare Renal Neoplasm-Case Report with Clinicopathologic Features and Review of the Literature.Case reports in pathology · 2023Article
- Pediatric onco-nephrology: time to spread the word : Part I: early kidney involvement in children with malignancy.Pediatric nephrology (Berlin, Germany) · 2021Article
- Review
- Imaging of DICER1 syndrome.Pediatric radiology · 2019Review
- Case - Mixed epithelial and stromal tumours: A rare pediatric renal tumour.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2019Article
- Anaplastic sarcomas of the kidney are characterized by DICER1 mutations.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Imaging of renal medullary carcinoma in children and young adults: a report from the Children's Oncology Group.Pediatric radiology · 2017Article
- Pediatric imaging in DICER1 syndrome.Pediatric radiology · 2017Article
- Pediatric Cystic Nephroma Is Morphologically, Immunohistochemically, and Genetically Distinct From Adult Cystic Nephroma.The American journal of surgical pathology · 2017Article
- Cystic Nephroma and its Varied Management Scenarios: A Report of two Cases.Journal of Indian Association of Pediatric SurgeonsArticle
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 1 country.
Funding
Abstract
Cystic nephromas (CNs) are uncommon benign renal neoplasms that present with a bimodal age distribution, affecting either infants/young children or adult females. Although differences between these age groups have been suggested, large studies of pediatric CN have not been conducted. As a result, the nomenclature and diagnostic criteria for these lesions remain controversial. In addition, the morphological overlap seen between CN and cystic partially differentiated nephroblastoma (CPDN) can result in diagnostic dilemmas. This study reviews the morphologic and radiographic features of 44 pediatric CN prospectively enrolled on a Children's Oncology Group protocol from 2007 to 2013. Although the typical multicystic architecture with thin septa described in adult CN was present in all of our pediatric cases, differences were also identified. We report distinctive features that add to the morphological spectrum of CN in children. Of the 44 cases, 16 had been previously analyzed and reported for DICER1 mutation, and either loss of function or missense mutations or both were identified in 15 of 16. In contrast, we analyzed 10 cases of adult CN, and all were negative for DICER1 mutations; similarly, 6 CPDNs previously analyzed and reported were negative for DICER1 mutations. Therefore, the clinical, morphological, and genetic differences between pediatric and adult CN, as well as between CN and CPDN, suggest that these 3 lesions represent distinct entities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.