ArticleProceedings of the National Academy of Sciences of the United States of America2016
A transcriptional signature of hub connectivity in the mouse connectome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 1 of them a synthesis that pooled it.
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Who cites it
129 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Network-Level Convergence of Adiposity-Related Gray Matter Alterations: A Coordinate-Based Connectome Mapping Meta-Analysis With Imaging Transcriptomics.Human brain mapping · 2026Pooled it
- Spatial organization of AQP4 water channel expression in the human brain.Science advances · 2026Article
- Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics.PLoS computational biology · 2026Article
- A canary in the mind: A single baseline brain scan predicts adolescent depression and anxiety one year later.medRxiv : the preprint server for health sciences · 2026Article
- Organization of neuropeptide systems in the human brain.Nature neuroscience · 2026Article
- Integrating optogenetic fMRI and spatial transcriptomics to reveal circuit-specific gene signatures in fronto- and hippo-thalamic networks.Nature communications · 2026Article
- Long-range axon branching: contributions to brain network plasticity and repair.Nature reviews. Neuroscience · 2026Review
- A data-driven framework linking the connectome to spatial gene expression gradients inspired by chemoaffinity theory.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Synapse types are spatially associated with regional hemodynamics in the mouse brain.PLoS biology · 2026Article
- Recent developments in imaging transcriptomics for psychiatric disorders.Psychoradiology · 2026Review
- Five energy metabolism pathways show distinct regional distributions and lifespan trajectories in the human brain.PLoS biology · 2026Article
- Heterogeneity-Aware, Multiscale Annotation of Shared and Specific Neurobiological Signatures among Major Neurodevelopmental Disorders.Research (Washington, D.C.) · 2026Article
- NeuroMArVL: An interactive and collaborative web-based tool for visualizing brain networks.Network neuroscience (Cambridge, Mass.) · 2026Article
- Transcriptomic divergence of network hubs in the prenatal human brain.Communications biology · 2025Article
- A framework to determine active neurons and networks within the mouse brain reveals how brain activity changes over the course of the day.PLoS biology · 2025Article
- Dynamic reorganization of individual-level morphological networks in unilateral frontal lobe low-grade gliomas: a longitudinal study.Journal of neuro-oncology · 2025Article
- Geometric constraints on the architecture of mammalian cortical connectomes.bioRxiv : the preprint server for biology · 2025Article
- Evolution of the Rich Club Properties in Mouse, Macaque, and Human Brain Networks: A Study of Functional Integration, Segregation, and Balance.Neuroscience bulletin · 2025Article
- Two subtypes of major depressive disorder are identified from individualized gray matter morphological abnormalities in a large multi-site dataset.Psychological medicine · 2025Article
- Genetic foundations of interindividual neurophysiological variability.Science advances · 2025Article
69 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
Connectivity is not distributed evenly throughout the brain. Instead, it is concentrated on a small number of highly connected neural elements that act as network hubs. Across different species and measurement scales, these hubs show dense interconnectivity, forming a core or "rich club" that integrates information across anatomically distributed neural systems. Here, we show that projections between connectivity hubs of the mouse brain are both central (i.e., they play an important role in neural communication) and costly (i.e., they extend over long anatomical distances) aspects of network organization that carry a distinctive genetic signature. Analyzing the neuronal connectivity of 213 brain regions and the transcriptional coupling, across 17,642 genes, between each pair of regions, we find that coupling is highest for pairs of connected hubs, intermediate for links between hubs and nonhubs, and lowest for connected pairs of nonhubs. The high transcriptional coupling associated with hub connectivity is driven by genes regulating the oxidative synthesis and metabolism of ATP--the primary energetic currency of neuronal communication. This genetic signature contrasts that identified for neuronal connectivity in general, which is driven by genes regulating neuronal, synaptic, and axonal structure and function. Our findings establish a direct link between molecular function and the large-scale topology of neuronal connectivity, showing that brain hubs display a tight coordination of gene expression, often over long anatomical distances, that is intimately related to the metabolic requirements of these highly active network elements.
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