Evidence map›Paper›PMID 26772171›Full record

Trial reportBMC geriatrics2016

Group-based exercise and cognitive-physical training in older adults with self-reported cognitive complaints: The Multiple-Modality, Mind-Motor (M4) study protocol.

Michael A Gregory, Dawn P Gill, Erin M Shellington, Teresa Liu-Ambrose, Ryosuke Shigematsu, Guangyong Zou, Kevin Shoemaker, Adrian M Owen, Vladimir Hachinski, Melanie Stuckey and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC geriatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02136368 (A Combined Exercise Program Plus Cognitive Training for Older Adults With Self-reported Cognitive Complaints), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02136368 nacompletednot on this map

A Combined Exercise Program Plus Cognitive Training for Older Adults With Self-reported Cognitive Complaints: The Multi-modal, Mind-motor (M4) Study

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2014 to 2016Enrolled127ConditionsCognitive Ability, GeneralArmsMulti-modal exercise, Mind-Motor Exercise, Balance and range of motion exercises
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Michael A GregoryHealth and Rehabilitation Sciences, Western University, London, ON, Canada. mgregor7@uwo.ca.
Dawn P GillLawson Health Research Institute, London, ON, Canada. dawn.gill@uwo.ca.
Erin M ShellingtonLawson Health Research Institute, London, ON, Canada. eshellin@uwo.ca.
Teresa Liu-AmbroseDepartment of Physical Therapy, University of British Columbia, Vancouver, BC, Canada. teresa.ambrose@ubc.ca.
Ryosuke ShigematsuFaculty of Education, Mie University, Tsu, Japan. rshige@edu.mie-u.ac.jp.
Guangyong ZouRobarts Clinical Trials of Robarts Research Institute, Western University, London, ON, Canada. gzou@robarts.ca.
Kevin ShoemakerSchool of Kinesiology, Western University, London, ON, Canada. kshoemak@uwo.ca.
Adrian M OwenThe Brain and Mind Institute, Western University, London, ON, Canada. adrian.owen@uwo.ca.
Vladimir HachinskiDepartment of Clinical Neurological Sciences, Western University, London, ON, Canada. Vladimir.Hachinski@lhsc.on.ca.
Melanie StuckeyCanadian Centre for Activity and Aging, Faculty of Health Sciences, Western University, London, ON, Canada. melstucke@uwo.ca.
Robert J PetrellaLawson Health Research Institute, London, ON, Canada. petrella@uwo.ca.
Western University · CALawson Health Research Institute · CAMie University · JPUniversity of British Columbia · CA

Funding

Canadian Institutes of Health Research MOP 130474
6 · The paper itself

Abstract

backgroundDementia is associated with cognitive and functional deficits, and poses a significant personal, societal, and economic burden. Directing interventions towards older adults with self-reported cognitive complaints may provide the greatest impact on dementia incidence and prevalence. Risk factors for cognitive and functional deficits are multifactorial in nature; many are cardiovascular disease risk factors and are lifestyle-mediated. Evidence suggests that multiple-modality exercise programs can provide cognitive and functional benefits that extend beyond what can be achieved from cognitive, aerobic, or resistance training alone, and preliminary evidence suggests that novel mind-motor interventions (i.e., Square Stepping Exercise; SSE) can benefit cognition and functional fitness. Nevertheless, it remains unclear whether multiple-modality exercise combined with mind-motor interventions can benefit diverse cognitive and functional outcomes in older adults with cognitive complaints. METHODS/

designThe Multiple-Modality, Mind-Motor (M4) study is a randomized controlled trial investigating the cognitive and functional impact of combined physical and cognitive training among community-dwelling adults with self-reported cognitive complaints who are 55 years of age or older. Participants are randomized to a Multiple-Modality and Mind-Motor (M4) intervention group or a Multiple-Modality (M2) comparison group. Participants exercise for 60 minutes/day, 3-days/week for 24 weeks and are assessed at baseline, 24 weeks and 52 weeks. The primary outcome is global cognitive function at 24 weeks, derived from the Cambridge Brain Sciences computerized cognitive battery. Secondary outcomes are: i) global cognitive function at 52 weeks; ii) domain-specific cognitive function at 24 and 52 weeks; iii) mobility (gait characteristics under single and dual-task conditions and balance); and 3) vascular health (blood pressure and carotid arterial measurements). We will analyze data based on an intent-to-treat approach, using mixed models for repeated measurements. DISCUSSION: The design features of the M4 trial and the methods included to address previous limitations within cognitive and exercise research will be discussed. Results from the M4 trial will provide evidence of combined multiple-modality and cognitive training among older adults with self-reported cognitive complaints on cognitive, mobility-related and vascular outcomes.

trial registrationClinicalTrials.gov NCT02136368.

Indexed as

DementiaLearningPsychomotor DisordersAgedAged, 80 and overCognitionExerciseExercise TherapyFemaleGaitHumansMaleMiddle AgedPsychomotor PerformanceSelf ReportTreatment Outcome

Identifiers

PMID26772171
PMCPMC4715303
OpenAlexW2260380204

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.