ArticlePLoS biology2016
Evolutionary Novelty in a Butterfly Wing Pattern through Enhancer Shuffling.
Article in PLoS biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed.
- A supergene and genomic mosaicism are associated with phenotypic evolution in Galápagos tree finches.Nature communications · 2026Article
- de novo Assembly of five Highly Contiguous Heliconius Butterfly Genomes With Long-Read Sequencing Alone.Genome biology and evolution · 2026Article
- Genetic parallelism underpins convergent mimicry coloration in Lepidoptera across 120 million years of evolution.PLoS biology · 2026Article
- A model-free method for genealogical inference without phasing and its application for topology weighting.Genetics · 2026Article
- Genomics of Neotropical biodiversity indicators: Two butterfly radiations with rampant chromosomal rearrangements and hybridization.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evolution of the essential geneProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Advances and challenges in understanding evolution through genome comparison: meeting report of the European Molecular Biology Organization (EMBO) lecture course "Evolutionary and Comparative Genomics".Bioinformatics advances · 2025Article
- Repeated Shifts in Sociality Are Associated With Fine-tuning of Highly Conserved and Lineage-Specific Enhancers in a Socially Flexible Bee.Molecular biology and evolution · 2024Article
- Article
- A distinct foliar pigmentation pattern formed by activator-repressor gradients upstream of an anthocyanin-activating R2R3-MYB.Cell reports · 2024Article
- Introgression Underlies Phylogenetic Uncertainty But Not Parallel Plumage Evolution in a Recent Songbird Radiation.Systematic biology · 2024Article
- Adaptive introgression of a visual preference gene.Science (New York, N.Y.) · 2024Article
- Pervasive mimicry in flight behavior among aposematic butterflies.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Transposable Element Insertions Are Associated with Batesian Mimicry in the Pantropical Butterfly Hypolimnas misippus.Molecular biology and evolution · 2024Article
- Common misconceptions of speciation.Evolutionary journal of the Linnean Society · 2024Review
- Major patterns in the introgression history ofeLife · 2023Article
- Demographically explicit scans for barriers to gene flow using gIMble.PLoS genetics · 2023Article
- Evidence for a single, ancient origin of a genus-wide alternative life history strategy.Science advances · 2023Article
- On the origin and structure of haplotype blocks.Molecular ecology · 2023Article
- A Phylogenomic Assessment of Processes Underpinning Convergent Evolution in Open-Habitat Chats.Molecular biology and evolution · 2023Article
12 more citing papers are in PubMed but not listed here.
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12 authors.
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Abstract
An important goal in evolutionary biology is to understand the genetic changes underlying novel morphological structures. We investigated the origins of a complex wing pattern found among Amazonian Heliconius butterflies. Genome sequence data from 142 individuals across 17 species identified narrow regions associated with two distinct red colour pattern elements, dennis and ray. We hypothesise that these modules in non-coding sequence represent distinct cis-regulatory loci that control expression of the transcription factor optix, which in turn controls red pattern variation across Heliconius. Phylogenetic analysis of the two elements demonstrated that they have distinct evolutionary histories and that novel adaptive morphological variation was created by shuffling these cis-regulatory modules through recombination between divergent lineages. In addition, recombination of modules into different combinations within species further contributes to diversity. Analysis of the timing of diversification in these two regions supports the hypothesis of introgression moving regulatory modules between species, rather than shared ancestral variation. The dennis phenotype introgressed into Heliconius melpomene at about the same time that ray originated in this group, while ray introgressed back into H. elevatus much more recently. We show that shuffling of existing enhancer elements both within and between species provides a mechanism for rapid diversification and generation of novel morphological combinations during adaptive radiation.
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