ArticlePloS one2016
Geometry Design Optimization of Functionally Graded Scaffolds for Bone Tissue Engineering: A Mechanobiological Approach.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Comparative Hydrodynamic Analysis and Optimization of Gyroid and Diamond Scaffolds with Functionally Graded Porosity.Journal of functional biomaterials · 2026Article
- Overview of porous magnesium-based scaffolds: development, properties and biomedical applications.Materials futures · 2025Review
- Bioinspired polypropylene-based functionally graded materials and metamaterials modeling the mistletoe-host interface.Beilstein journal of nanotechnology · 2025Article
- Mechanobiological optimization of scaffolds for bone tissue engineering.Biomechanics and modeling in mechanobiology · 2024Article
- Recent advances in artificial intelligent strategies for tissue engineering and regenerative medicine.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Review
- Research on Dual-Phase Composite Forming Process and Platform Construction of Radial Gradient Long Bone Scaffold.Bioengineering (Basel, Switzerland) · 2024Article
- Optimization of Cobalt-Chromium (Co-Cr) Scaffolds for Bone Tissue Engineering in Endocrine, Metabolic and Immune Disorders.Endocrine, metabolic & immune disorders drug targets · 2024Review
- An overview of 3D printed metal implants in orthopedic applications: Present and future perspectives.Heliyon · 2023Review
- FLIM imaging revealed spontaneous osteogenic differentiation of stem cells on gradient pore size tissue-engineered constructs.Stem cell research & therapy · 2023Article
- Ceramic Materials for Biomedical Applications: An Overview on Properties and Fabrication Processes.Journal of functional biomaterials · 2023Review
- Study on the influence of scaffold morphology and structure on osteogenic performance.Frontiers in bioengineering and biotechnology · 2023Review
- Computational Analysis and Optimization of Geometric Parameters for Fibrous Scaffold Design.ACS omega · 2022Article
- Wall Shear Stress Analysis and Optimization in Tissue Engineering TPMS Scaffolds.Materials (Basel, Switzerland) · 2022Article
- A Novel Design Method of Gradient Porous Structure for Stabilized and Lightweight Mandibular Prosthesis.Bioengineering (Basel, Switzerland) · 2022Article
- 3D Printing of Hierarchically Porous Lattice Structures Based on Åkermanite Glass Microspheres and Reactive Silicone Binder.Journal of functional biomaterials · 2022Article
- A mechanobiological computer optimization framework to design scaffolds to enhance bone regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Challenges in computational fluid dynamics applications for bone tissue engineering.Proceedings. Mathematical, physical, and engineering sciences · 2022Review
- Initial mechanical conditions within an optimized bone scaffold do not ensure bone regeneration - an in silico analysis.Biomechanics and modeling in mechanobiology · 2021Article
- Osteo-mucosal engineered construct: In situ adhesion of hard-soft tissues.Materials science & engineering. C, Materials for biological applications · 2021Article
- Application of Computational Method in Designing a Unit Cell of Bone Tissue Engineering Scaffold: A Review.Polymers · 2021Review
Corrections and comments
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5 authors.
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Abstract
Functionally Graded Scaffolds (FGSs) are porous biomaterials where porosity changes in space with a specific gradient. In spite of their wide use in bone tissue engineering, possible models that relate the scaffold gradient to the mechanical and biological requirements for the regeneration of the bony tissue are currently missing. In this study we attempt to bridge the gap by developing a mechanobiology-based optimization algorithm aimed to determine the optimal graded porosity distribution in FGSs. The algorithm combines the parametric finite element model of a FGS, a computational mechano-regulation model and a numerical optimization routine. For assigned boundary and loading conditions, the algorithm builds iteratively different scaffold geometry configurations with different porosity distributions until the best microstructure geometry is reached, i.e. the geometry that allows the amount of bone formation to be maximized. We tested different porosity distribution laws, loading conditions and scaffold Young's modulus values. For each combination of these variables, the explicit equation of the porosity distribution law-i.e the law that describes the pore dimensions in function of the spatial coordinates-was determined that allows the highest amounts of bone to be generated. The results show that the loading conditions affect significantly the optimal porosity distribution. For a pure compression loading, it was found that the pore dimensions are almost constant throughout the entire scaffold and using a FGS allows the formation of amounts of bone slightly larger than those obtainable with a homogeneous porosity scaffold. For a pure shear loading, instead, FGSs allow to significantly increase the bone formation compared to a homogeneous porosity scaffolds. Although experimental data is still necessary to properly relate the mechanical/biological environment to the scaffold microstructure, this model represents an important step towards optimizing geometry of functionally graded scaffolds based on mechanobiological criteria.
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