Evidence map›Paper›PMID 26771705›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2016

Effects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers.

Christopher J Morris, Taylor E Purvis, Joseph Mistretta, Frank A J L Scheer

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03647306 (Behavioral Chronotype), which is not on this map. Cited by 143 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 2 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03647306 naactive not recruitingnot on this mapstarted 2018, after this paper: background citation

Behavioral Chronotype: Impact on Sleep and Metabolism

TypeinterventionalSponsorUniversity of ChicagoRan2018 to 2027Enrolled200ConditionsType2 Diabetes Mellitus, Cardiovascular DiseasesArmsEarly Total Caloric Intake, Late Total Caloric Intake, Extended Overnight Fast
3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 2 syntheses or guidelines pooled it, 252 citations in OpenAlex.

  1. A Systematic Review of Nutrition Interventions for Shift Workers, With Subgroup Analysis of First Responder Populations.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Christopher J MorrisMedical Chronobiology Program (C.J.M., T.E.P., J.M., F.A.J.L.S.), Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts 02115; and Division of Sleep Medicine (C.J.M., F.A.J.L.S.), Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.
Taylor E PurvisMedical Chronobiology Program (C.J.M., T.E.P., J.M., F.A.J.L.S.), Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts 02115; and Division of Sleep Medicine (C.J.M., F.A.J.L.S.), Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.
Joseph MistrettaMedical Chronobiology Program (C.J.M., T.E.P., J.M., F.A.J.L.S.), Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts 02115; and Division of Sleep Medicine (C.J.M., F.A.J.L.S.), Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.
Frank A J L ScheerMedical Chronobiology Program (C.J.M., T.E.P., J.M., F.A.J.L.S.), Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts 02115; and Division of Sleep Medicine (C.J.M., F.A.J.L.S.), Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.
Brigham and Women's Hospital · USHarvard University · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Meal Time Effects on Metabolic Health.R01DK099512 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2014 to 2017
$2.8M
Development of countermeasures against adverse metabolic effects of shift workR01HL118601 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2014 to 2017
$2.6M
Mechanisms underlying adverse health consequences of shift workR01HL094806 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2009 to 2013
$1.6M
NCRR NIH HHS UL1 RR025758NCRR NIH HHS UL1RR025758NHLBI NIH HHS R01 HL094806NHLBI NIH HHS R01 HL118601NIDDK NIH HHS R01 DK099512
6 · The paper itself

Abstract

contextShift work is a risk factor for diabetes. The separate effects of the endogenous circadian system and circadian misalignment (ie, misalignment between the central circadian pacemaker and 24-hour environmental/behavioral rhythms such as the light/dark and feeding/fasting cycles) on glucose tolerance in shift workers are unknown.

objectiveThe objective of the study was to test the hypothesis that the endogenous circadian system and circadian misalignment separately affect glucose tolerance in shift workers, both independently from behavioral cycle effects.

designA randomized, crossover study with two 3-day laboratory visits.

settingCenter for Clinical Investigation at Brigham and Women's Hospital. PATIENTS: Healthy chronic shift workers.

interventionThe intervention included simulated night work comprised of 12-hour inverted behavioral and environmental cycles (circadian misalignment) or simulated day work (circadian alignment).

main outcome measuresPostprandial glucose and insulin responses to identical meals given at 8:00 am and 8:00 pm in both protocols.

resultsPostprandial glucose was 6.5% higher at 8:00 pm than 8:00 am (circadian phase effect), independent of behavioral effects (P = .0041). Circadian misalignment increased postprandial glucose by 5.6%, independent of behavioral and circadian effects (P = .0042). These variations in glucose tolerance appeared to be explained, at least in part, by different insulin mechanisms: during the biological evening by decreased pancreatic β-cell function (18% lower early and late phase insulin; both P ≤ .011) and during circadian misalignment presumably by decreased insulin sensitivity (elevated postprandial glucose despite 10% higher late phase insulin; P = .015) without change in early-phase insulin (P = .38).

conclusionsInternal circadian time affects glucose tolerance in shift workers. Separately, circadian misalignment reduces glucose tolerance in shift workers, providing a mechanism to help explain the increased diabetes risk in shift workers.

Indexed as

AdultBlood GlucoseChronobiology DisordersCircadian RhythmCross-Over StudiesDietFemaleGlucose IntoleranceHumansHydrocortisoneInsulinInsulin-Secreting CellsMaleMealsMiddle AgedPostprandial PeriodBlood GlucoseHydrocortisoneInsulin

Identifiers

PMID26771705
PMCPMC4803172
OpenAlexW2237552187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.