Evidence map›Paper›PMID 26771674›Full record

ReviewCurrent opinion in microbiology2016

The unmasking of 'junk' RNA reveals novel sRNAs: from processed RNA fragments to marooned riboswitches.

Nicholas R De Lay, Danielle A Garsin

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Rli51 Attenuates Transcription of theInternational journal of molecular sciences · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Riboswitch regulation in cyanobacteria is independent of their habitat adaptations.Physiology and molecular biology of plants : an international journal of functional plant biology · 2018
    Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nicholas R De LayDepartment of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX 77030, USA. Electronic address: nicholas.r.delay@uth.tmc.edu.
Danielle A GarsinDepartment of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX 77030, USA. Electronic address: danielle.a.garsin@uth.tmc.edu.
The University of Texas Health Science Center at Houston · US

Funding

The Role of Reactive Oxygen Species in Mucosal Innate ImmunityR01AI076406 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A · 2009 to 2019
$3.2M
Post-initiation regulatory mechanisms controlling ethanolamine utilizationR01AI110432 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A, WINKLER, WADE · 2015 to 2019
$2.2M
NIAID NIH HHS R01 AI076406NIAID NIH HHS R01 AI110432NIAID NIH HHS R01AI110432
6 · The paper itself

Abstract

While the notion that RNAs can function as regulators dates back to early molecular studies of gene regulation of the lac operon, it is only over the last decade that the ubiquity and diversity of regulatory RNAs are being realized. Advancements in high throughput sequencing and the adoption of these approaches to rapidly sequence genomes and transcriptomes and to examine gene expression and RNA binding protein specificity have revealed an ever-expanding RNA world. In this review, we focus on recent studies revealing that RNA fragments cleaved from larger coding or noncoding RNAs can have regulatory functions. Additionally, we discuss examples of riboswitches that function in trans as mRNA or protein-binding sRNAs, upending the traditional thinking that these are exclusively cis-acting elements.

Indexed as

RiboswitchBacteriaRNA, BacterialRNA, Small UntranslatedRiboswitchRNA, BacterialRNA, Small Untranslated

Identifiers

PMID26771674
PMCPMC4821684
OpenAlexW2223269434

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.