ArticleMolecules (Basel, Switzerland)2016
Role of Nitric Oxide and Hydrogen Sulfide in the Vasodilator Effect of Ursolic Acid and Uvaol from Black Cherry Prunus serotina Fruits.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Traditional Chinese medicine method of tonifying kidney for hypertension: Clinical evidence and molecular mechanisms.Frontiers in cardiovascular medicine · 2022Pooled it
- Exploring the phytochemical composition, ethnomedicinal uses, and therapeutic potential of Prunus species: a comprehensive review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Active Constituents and Mechanisms of Xinshubao Tablets in Coronary Vasorelaxation.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Article
- Mechanism-based and computational modeling of hydrogen sulfide biogenesis inhibition: interfacial inhibition.Scientific reports · 2023Article
- Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update.Nutrients · 2022Review
- Bioassay's Directed Isolation-Structure Elucidation and Molecular Docking of Triterpenes fromEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Performance of Olive-Pomace Oils in Discontinuous and Continuous Frying. Comparative Behavior with Sunflower Oils and High-Oleic Sunflower Oils.Foods (Basel, Switzerland) · 2021Article
- Stability of Bioactive Compounds in Olive-Pomace Oil at Frying Temperature and Incorporation into Fried Foods.Foods (Basel, Switzerland) · 2021Article
- Beneficial Effects of Ursolic Acid and Its Derivatives-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions.Nutrients · 2021Review
- Secondary Metabolites of Plants as Modulators of Endothelium Functions.International journal of molecular sciences · 2021Review
- Uvaol Improves the Functioning of Fibroblasts and Endothelial Cells and Accelerates the Healing of Cutaneous Wounds in Mice.Molecules (Basel, Switzerland) · 2020Article
- Phytopharmacological Possibilities of Bird CherryNutrients · 2020Review
- Vasorelaxant Effect ofMolecules (Basel, Switzerland) · 2019Article
- Endothelium-Dependent Vasorelaxant Effect ofNutrients · 2019Article
- Vasorelaxant activities and the underlying pharmacological mechanisms of Gynura procumbens Merr. leaf extracts on rat thoracic aorta.Inflammopharmacology · 2019Article
- Vasodilation Elicited by Isoxsuprine, Identified by High-Throughput Virtual Screening of Compound Libraries, Involves Activation of the NO/cGMP and H₂S/KMolecules (Basel, Switzerland) · 2019Article
- Vasodilator Activity of Compounds Isolated from Plants Used in Mexican Traditional Medicine.Molecules (Basel, Switzerland) · 2018Article
- Cardioprotective Effects ofJournal of evidence-based integrative medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present research aimed to isolate the non-polar secondary metabolites that produce the vasodilator effects induced by the dichloromethane extract of Prunus serotina (P. serotina) fruits and to determine whether the NO/cGMP and the H2S/KATP channel pathways are involved in their mechanism of action. A bioactivity-directed fractionation of the dichloromethane extract of P. serotina fruits led to the isolation of ursolic acid and uvaol as the main non-polar vasodilator compounds. These compounds showed significant relaxant effect on rat aortic rings in an endothelium- and concentration-dependent manner, which was inhibited by NG-nitro-L-arginine methyl ester (L-NAME), DL-propargylglycine (PAG) and glibenclamide (Gli). Additionally, both triterpenes increased NO and H2S production in aortic tissue. Molecular docking studies showed that ursolic acid and uvaol are able to bind to endothelial NOS and CSE with high affinity for residues that form the oligomeric interface of both enzymes. These results suggest that the vasodilator effect produced by ursolic acid and uvaol contained in P. serotina fruits, involves activation of the NO/cGMP and H2S/KATP channel pathways, possibly through direct activation of NOS and CSE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.