ArticlePLoS genetics2016
A Spatial Framework for Understanding Population Structure and Admixture.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Estimating human mobility in Holocene Western Eurasia with large-scale ancient genomic data.Proceedings of the National Academy of Sciences of the United States of America · 2023Pooled it
- FRAME: Fine-Resolution Asymmetric Migration Estimation.Nature communications · 2026Article
- Exploring Genetic Diversity in a Core Collection of Aegilops tauschii Coss. Populations Using iPBS and SCoT Markers.Biochemical genetics · 2026Article
- Reflections on the Human Genome Diversity Project: a conversation with Marcus W. Feldman, Henry T. Greely, and Mary-Claire King.Genetics · 2026Article
- Evaluating inbreeding and assessing the risk of outbreeding depression in genetic rescue using whole-genome sequence data.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The genomic history of East Asian Middle Neolithic millet- and rice-agricultural populations.Cell genomics · 2025Article
- Jointly representing long-range genetic similarity and spatially heterogeneous isolation-by-distance.PLoS genetics · 2025Article
- Everchanging range: how the changing environment has influenced the genetic diversity and differentiation of an iconic North American palm species.Annals of botany · 2025Article
- High resolution class I HLA-A, -B, and -C diversity in Eastern and Southern African populations.Scientific reports · 2025Article
- The interplay among space, environment, and gene flow drives genetic differentiation in endemic Baja California Agave sobria subspecies.American journal of botany · 2025Article
- GeoGenIE: a deep learning approach to predict geographic provenance of biodiversity samples from genomic SNPs.Bioinformatics advances · 2025Article
- Article
- Genetic homogeneity and weak signatures of local adaptation in the marine mussel Mytilus chilensis.Scientific reports · 2024Article
- Deep history of cultural and linguistic evolution among Central African hunter-gatherers.Nature human behaviour · 2024Article
- Genetic characterization of cashmere goat (Frontiers in genetics · 2024Article
- Article
- Evolutionary history ofAoB PLANTS · 2023Article
- Historical biogeography and local adaptation explain population genetic structure in a widespread terrestrial orchid.Annals of botany · 2023Article
- A genetic and linguistic analysis of the admixture histories of the islands of Cabo Verde.eLife · 2023Article
- Isolation by distance in populations with power-law dispersal.G3 (Bethesda, Md.) · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Geographic patterns of genetic variation within modern populations, produced by complex histories of migration, can be difficult to infer and visually summarize. A general consequence of geographically limited dispersal is that samples from nearby locations tend to be more closely related than samples from distant locations, and so genetic covariance often recapitulates geographic proximity. We use genome-wide polymorphism data to build "geogenetic maps," which, when applied to stationary populations, produces a map of the geographic positions of the populations, but with distances distorted to reflect historical rates of gene flow. In the underlying model, allele frequency covariance is a decreasing function of geogenetic distance, and nonlocal gene flow such as admixture can be identified as anomalously strong covariance over long distances. This admixture is explicitly co-estimated and depicted as arrows, from the source of admixture to the recipient, on the geogenetic map. We demonstrate the utility of this method on a circum-Tibetan sampling of the greenish warbler (Phylloscopus trochiloides), in which we find evidence for gene flow between the adjacent, terminal populations of the ring species. We also analyze a global sampling of human populations, for which we largely recover the geography of the sampling, with support for significant histories of admixture in many samples. This new tool for understanding and visualizing patterns of population structure is implemented in a Bayesian framework in the program SpaceMix.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.