Evidence map›Paper›PMID 26771020›Full record

ArticleCell systems2015

Orientation of Turing-like Patterns by Morphogen Gradients and Tissue Anisotropies.

Tom W Hiscock, Sean G Megason

Abstract read
In one paragraph

Article in Cell systems, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. How nature discovers rare Turing islands: Exploration by common limit cycles.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Development shapes the evolutionary diversification of rodent stripe patterns.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Article
  11. Axial segmentation by iterative mechanical signaling.bioRxiv : the preprint server for biology · 2023
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Of mitogens and morphogens: modelling Sonic Hedgehog mechanisms in vertebrate development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tom W HiscockDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Sean G MegasonDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

Funding

Microscope purchase for R01 Dynamic regulatory mechanisms of robust pattern formation in the neural tubeR01GM107733 · NIGMS · HARVARD MEDICAL SCHOOL · PI MEGASON, SEAN G · 2015 to 2022
$2.8M
In toto imaging and genomics to decode ear hair cell formation and regenerationR01DC010791 · NIDCD · HARVARD MEDICAL SCHOOL · PI MEGASON, SEAN G · 2010 to 2014
$2.1M
NIDCD NIH HHS R01 DC010791NIGMS NIH HHS R01 GM107733
6 · The paper itself

Abstract

Patterning of periodic stripes during development requires mechanisms to control both stripe spacing and orientation. A number of models can explain how stripe spacing is controlled, including molecular mechanisms, such as Turing's reaction-diffusion model, as well as cell-based and mechanical mechanisms. However, how stripe orientation is controlled in each of these cases is poorly understood. Here, we model stripe orientation using a simple, yet generic model of periodic patterning, with the aim of finding qualitative features of stripe orientation that are mechanism-independent. Our model predicts three qualitatively distinct classes of orientation mechanism: gradients in production rates, gradients in model parameters, and anisotropies (e.g. in diffusion or growth). We provide evidence that the results from our minimal model may also apply to more specific and complex models, revealing features of stripe orientation that may be common to a variety of biological systems.

Identifiers

PMID26771020
PMCPMC4707970

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.