ArticleJournal of diabetes research2016
Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research).
Article in Journal of diabetes research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Neck circumference as a metabolic health marker among women with polycystic ovary syndrome (PCOS): a systematic review and meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Trial
- Exercise Increases Insulin Sensitivity and Skeletal Muscle AMPK Expression in Systemic Lupus Erythematosus: A Randomized Controlled Trial.Frontiers in immunology · 2018Trial
- Nine anthropometric insulin resistance indices predict mortality and life expectancy across glucose states.iScience · 2026Article
- Influence of metabolism-related comorbidities and insulin resistance on new onset of chronic kidney disease in a health check-up population: a two-stage retrospective cohort study.BMJ open diabetes research & care · 2025Article
- Impact of Insulin-Induced Relative Hypoglycemia on Vascular Insulin Sensitivity and Central Hemodynamics in Prediabetes.The Journal of clinical endocrinology and metabolism · 2025Article
- Association between triglyceride-glucose and triglyceride glucose body mass index with risk of prediabetes: a multicenter Chinese medical examination cohort study.Frontiers in endocrinology · 2025Article
- Social isolation increases impulsive choice with minor changes on metabolic function in middle-aged rats.Physiological reports · 2025Article
- Insulin enhances acid-sensing ion channel currents in rat primary sensory neurons.Scientific reports · 2024Article
- Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system.The journal of headache and pain · 2022Article
- Consuming Sucrose- or HFCS-sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults.The Journal of clinical endocrinology and metabolism · 2021Article
- Metabolic Parameters in Patients with Suspected Reactive Hypoglycemia.Journal of personalized medicine · 2021Article
- Review
- DPP-4 inhibition resembles exercise in preventing type 2 diabetes development by inhibiting hepatic protein kinase CThe Journal of international medical research · 2020Article
- Therapy to Obese Type 2 Diabetes Mellitus: How Far Will We Go Down the Wrong Road?Chinese journal of integrative medicine · 2020Review
- High fructose-containing drinking water-induced steatohepatitis in rats is prevented by the nicotinamide-mediated modulation of redox homeostasis and NADPH-producing enzymes.Molecular biology reports · 2020Article
- Article
- Assessment of insulin sensitivity and secretion in patients with fibrocalculous pancreatic diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers.Respiratory research · 2018Article
- Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China.Lipids in health and disease · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the differences in insulin resistance (IR) among subjects with normal glucose tolerance (NGT), hyperinsulinemia with NGT (HINS), impaired glucose tolerance (IGT), and newly diagnosed type 2 diabetes mellitus (T2DM).
methods5 NGT, 25 HINS, 25 IGT, and 25 T2DM subjects participated in this research. The hyperinsulinemic-euglycemic clamp technique (HECT) was performed in all of them to evaluate IR levels. The relative factors influencing IR were evaluated. The simple insulin sensitivity indices were calculated, and the correlation between each index and the M value was analyzed.
resultsThe M values of NGT, HINS, IGT, and T2DM groups were 11.88 ± 2.93 mg · kg(-1) · min(-1), 6.23 ± 1.73 mg · kg(-1) · min(-1), 6.37 ± 2.12 mg · kg(-1) · min(-1), and 6.19 ± 1.89 mg · kg(-1) · min(-1), respectively. M values in HINS, IGT, and T2DM groups were lower than those in the NGT group (P = 0.005); however, the differences among the HINS, IGT, and T2DM groups were not statistically significant (P = 0.835). The independent factors influencing the M value were waistline and fasting insulin level (FINS). The simple insulin sensitivity indices, especially Matsuda and Gutt index, were significantly associated with the M value (P < 0.01).
conclusionIR existed in the HINS, IGT, and T2DM groups, and IR levels were consistent in the three groups. The independent factors influencing IR were waistline and FINS.
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