Evidence map›Paper›PMID 26770960›Full record

ArticleCMAJ open

Maternal placental syndromes among women living with HIV in Ontario: a population-based study.

Ryan Ng, Erin M Macdonald, Mark H Yudin, Ahmed M Bayoumi, Mona R Loutfy, Janet Raboud, Khatundi-Irene Masinde, Wangari E Tharao, Jason Brophy, Richard H Glazier and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CMAJ open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Placental Structure in Preterm Birth Among HIV-Positive Versus HIV-Negative Women in Kenya.Journal of acquired immune deficiency syndromes (1999) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ryan NgInstitute for Clinical Evaluative Sciences (Ng, Macdonald, Loutfy, Raboud, Glazier, Antoniou); Li Ka Shing Knowledge Institute (Yudin, Antoniou, Bayoumi), St. Michael's Hospital; Centre for Research on Inner City Health (Yudin, Bayoumi), St. Michael's Hospital; Department of Obstetrics and Gynecology (Yudin), St. Michael's Hospital and University of Toronto; Department of Medicine (Loutfy, Bayoumi), University of Toronto; Women's College Research Institute (Loutfy, Masinde), Women's College Hospital; Toronto General Research Institute (Raboud), University Health Network; Dalla Lana School of Public Health (Raboud), University of Toronto; Women's Health in Women's Hands Community Health Centre (Tharao), Toronto, Ont.; Children's Hospital of Eastern Ontario and University of Ottawa (Brophy), Ottawa, Ont.; Department of Family and Community Medicine (Glazier, Antoniou), St. Michael's Hospital and University of Toronto, Toronto, Ont.
Erin M MacdonaldInstitute for Clinical Evaluative Sciences (Ng, Macdonald, Loutfy, Raboud, Glazier, Antoniou); Li Ka Shing Knowledge Institute (Yudin, Antoniou, Bayoumi), St. Michael's Hospital; Centre for Research on Inner City Health (Yudin, Bayoumi), St. Michael's Hospital; Department of Obstetrics and Gynecology (Yudin), St. Michael's Hospital and University of Toronto; Department of Medicine (Loutfy, Bayoumi), University of Toronto; Women's College Research Institute (Loutfy, Masinde), Women's College Hospital; Toronto General Research Institute (Raboud), University Health Network; Dalla Lana School of Public Health (Raboud), University of Toronto; Women's Health in Women's Hands Community Health Centre (Tharao), Toronto, Ont.; Children's Hospital of Eastern Ontario and University of Ottawa (Brophy), Ottawa, Ont.; Department of Family and Community Medicine (Glazier, Antoniou), St. Michael's Hospital and University of Toronto, Toronto, Ont.
Mark H YudinInstitute for Clinical Evaluative Sciences (Ng, Macdonald, Loutfy, Raboud, Glazier, Antoniou); Li Ka Shing Knowledge Institute (Yudin, Antoniou, Bayoumi), St. Michael's Hospital; Centre for Research on Inner City Health (Yudin, Bayoumi), St. Michael's Hospital; Department of Obstetrics and Gynecology (Yudin), St. Michael's Hospital and University of Toronto; Department of Medicine (Loutfy, Bayoumi), University of Toronto; Women's College Research Institute (Loutfy, Masinde), Women's College Hospital; Toronto General Research Institute (Raboud), University Health Network; Dalla Lana School of Public Health (Raboud), University of Toronto; Women's Health in Women's Hands Community Health Centre (Tharao), Toronto, Ont.; Children's Hospital of Eastern Ontario and University of Ottawa (Brophy), Ottawa, Ont.; Department of Family and Community Medicine (Glazier, Antoniou), St. Michael's Hospital and University of Toronto, Toronto, Ont.
Ahmed M BayoumiInstitute for Clinical Evaluative Sciences (Ng, Macdonald, Loutfy, Raboud, Glazier, Antoniou); Li Ka Shing Knowledge Institute (Yudin, Antoniou, Bayoumi), St. Michael's Hospital; Centre for Research on Inner City Health (Yudin, Bayoumi), St. Michael's Hospital; Department of Obstetrics and Gynecology (Yudin), St. Michael's Hospital and University of Toronto; Department of Medicine (Loutfy, Bayoumi), University of Toronto; Women's College Research Institute (Loutfy, Masinde), Women's College Hospital; Toronto General Research Institute (Raboud), University Health Network; Dalla Lana School of Public Health (Raboud), University of Toronto; Women's Health in Women's Hands Community Health Centre (Tharao), Toronto, Ont.; Children's Hospital of Eastern Ontario and University of Ottawa (Brophy), Ottawa, Ont.; Department of Family and Community Medicine (Glazier, Antoniou), St. Michael's Hospital and University of Toronto, Toronto, Ont.
Mona R LoutfyInstitute for Clinical Evaluative Sciences (Ng, Macdonald, Loutfy, Raboud, Glazier, Antoniou); Li Ka Shing Knowledge Institute (Yudin, Antoniou, Bayoumi), St. Michael's Hospital; Centre for Research on Inner City Health (Yudin, Bayoumi), St. Michael's Hospital; Department of Obstetrics and Gynecology (Yudin), St. Michael's Hospital and University of Toronto; Department of Medicine (Loutfy, Bayoumi), University of Toronto; Women's College Research Institute (Loutfy, Masinde), Women's College Hospital; Toronto General Research Institute (Raboud), University Health Network; Dalla Lana School of Public Health (Raboud), University of Toronto; Women's Health in Women's Hands Community Health Centre (Tharao), Toronto, Ont.; Children's Hospital of Eastern Ontario and University of Ottawa (Brophy), Ottawa, Ont.; Department of Family and Community Medicine (Glazier, Antoniou), St. Michael's Hospital and University of Toronto, Toronto, Ont.
Janet RaboudInstitute for Clinical Evaluative Sciences (Ng, Macdonald, Loutfy, Raboud, Glazier, Antoniou); Li Ka Shing Knowledge Institute (Yudin, Antoniou, Bayoumi), St. Michael's Hospital; Centre for Research on Inner City Health (Yudin, Bayoumi), St. Michael's Hospital; Department of Obstetrics and Gynecology (Yudin), St. Michael's Hospital and University of Toronto; Department of Medicine (Loutfy, Bayoumi), University of Toronto; Women's College Research Institute (Loutfy, Masinde), Women's College Hospital; Toronto General Research Institute (Raboud), University Health Network; Dalla Lana School of Public Health (Raboud), University of Toronto; Women's Health in Women's Hands Community Health Centre (Tharao), Toronto, Ont.; Children's Hospital of Eastern Ontario and University of Ottawa (Brophy), Ottawa, Ont.; Department of Family and Community Medicine (Glazier, Antoniou), St. Michael's Hospital and University of Toronto, Toronto, Ont.
Khatundi-Irene MasindeInstitute for Clinical Evaluative Sciences (Ng, Macdonald, Loutfy, Raboud, Glazier, Antoniou); Li Ka Shing Knowledge Institute (Yudin, Antoniou, Bayoumi), St. Michael's Hospital; Centre for Research on Inner City Health (Yudin, Bayoumi), St. Michael's Hospital; Department of Obstetrics and Gynecology (Yudin), St. Michael's Hospital and University of Toronto; Department of Medicine (Loutfy, Bayoumi), University of Toronto; Women's College Research Institute (Loutfy, Masinde), Women's College Hospital; Toronto General Research Institute (Raboud), University Health Network; Dalla Lana School of Public Health (Raboud), University of Toronto; Women's Health in Women's Hands Community Health Centre (Tharao), Toronto, Ont.; Children's Hospital of Eastern Ontario and University of Ottawa (Brophy), Ottawa, Ont.; Department of Family and Community Medicine (Glazier, Antoniou), St. Michael's Hospital and University of Toronto, Toronto, Ont.
Wangari E TharaoInstitute for Clinical Evaluative Sciences (Ng, Macdonald, Loutfy, Raboud, Glazier, Antoniou); Li Ka Shing Knowledge Institute (Yudin, Antoniou, Bayoumi), St. Michael's Hospital; Centre for Research on Inner City Health (Yudin, Bayoumi), St. Michael's Hospital; Department of Obstetrics and Gynecology (Yudin), St. Michael's Hospital and University of Toronto; Department of Medicine (Loutfy, Bayoumi), University of Toronto; Women's College Research Institute (Loutfy, Masinde), Women's College Hospital; Toronto General Research Institute (Raboud), University Health Network; Dalla Lana School of Public Health (Raboud), University of Toronto; Women's Health in Women's Hands Community Health Centre (Tharao), Toronto, Ont.; Children's Hospital of Eastern Ontario and University of Ottawa (Brophy), Ottawa, Ont.; Department of Family and Community Medicine (Glazier, Antoniou), St. Michael's Hospital and University of Toronto, Toronto, Ont.
Jason BrophyInstitute for Clinical Evaluative Sciences (Ng, Macdonald, Loutfy, Raboud, Glazier, Antoniou); Li Ka Shing Knowledge Institute (Yudin, Antoniou, Bayoumi), St. Michael's Hospital; Centre for Research on Inner City Health (Yudin, Bayoumi), St. Michael's Hospital; Department of Obstetrics and Gynecology (Yudin), St. Michael's Hospital and University of Toronto; Department of Medicine (Loutfy, Bayoumi), University of Toronto; Women's College Research Institute (Loutfy, Masinde), Women's College Hospital; Toronto General Research Institute (Raboud), University Health Network; Dalla Lana School of Public Health (Raboud), University of Toronto; Women's Health in Women's Hands Community Health Centre (Tharao), Toronto, Ont.; Children's Hospital of Eastern Ontario and University of Ottawa (Brophy), Ottawa, Ont.; Department of Family and Community Medicine (Glazier, Antoniou), St. Michael's Hospital and University of Toronto, Toronto, Ont.
Richard H GlazierInstitute for Clinical Evaluative Sciences (Ng, Macdonald, Loutfy, Raboud, Glazier, Antoniou); Li Ka Shing Knowledge Institute (Yudin, Antoniou, Bayoumi), St. Michael's Hospital; Centre for Research on Inner City Health (Yudin, Bayoumi), St. Michael's Hospital; Department of Obstetrics and Gynecology (Yudin), St. Michael's Hospital and University of Toronto; Department of Medicine (Loutfy, Bayoumi), University of Toronto; Women's College Research Institute (Loutfy, Masinde), Women's College Hospital; Toronto General Research Institute (Raboud), University Health Network; Dalla Lana School of Public Health (Raboud), University of Toronto; Women's Health in Women's Hands Community Health Centre (Tharao), Toronto, Ont.; Children's Hospital of Eastern Ontario and University of Ottawa (Brophy), Ottawa, Ont.; Department of Family and Community Medicine (Glazier, Antoniou), St. Michael's Hospital and University of Toronto, Toronto, Ont.
Tony AntoniouInstitute for Clinical Evaluative Sciences (Ng, Macdonald, Loutfy, Raboud, Glazier, Antoniou); Li Ka Shing Knowledge Institute (Yudin, Antoniou, Bayoumi), St. Michael's Hospital; Centre for Research on Inner City Health (Yudin, Bayoumi), St. Michael's Hospital; Department of Obstetrics and Gynecology (Yudin), St. Michael's Hospital and University of Toronto; Department of Medicine (Loutfy, Bayoumi), University of Toronto; Women's College Research Institute (Loutfy, Masinde), Women's College Hospital; Toronto General Research Institute (Raboud), University Health Network; Dalla Lana School of Public Health (Raboud), University of Toronto; Women's Health in Women's Hands Community Health Centre (Tharao), Toronto, Ont.; Children's Hospital of Eastern Ontario and University of Ottawa (Brophy), Ottawa, Ont.; Department of Family and Community Medicine (Glazier, Antoniou), St. Michael's Hospital and University of Toronto, Toronto, Ont.
St Michael's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaternal placental syndromes are associated with adverse fetal outcomes and maternal cardiovascular disease. However, whether HIV infection increases the risk of maternal placental syndromes is unknown. Our objective was to compare the risk of maternal placental syndromes between women living with and without HIV infection in Ontario.

methodsWe conducted a population-based study using health administrative data from Ontario. We identified all pregnancies resulting in a live birth between Apr. 1, 2002, and Mar. 31, 2011; we identified women living with HIV using a validated case-finding algorithm. Our primary composite outcome was maternal placental syndromes, defined as a diagnosis of preeclampsia, eclampsia, placental abruption or placental infarction. We used generalized estimating equations with a logit link function to derive adjusted odds ratios (AORs) and 95% confidence intervals (CI) for the association between HIV infection and maternal placental syndromes.

resultsData from 1 132 871 pregnancies were available for analysis; 634 (0.06%) of the pregnancies were in women living with HIV. After multivariable adjustment, we found no difference in the risk of maternal placental syndromes between women living with HIV and those without HIV infection (5.8% v. 5.6%; AOR 0.85 [95% CI 0.59-1.21]). An increased risk of maternal placental syndromes was associated with pre-existing diabetes (AOR 1.47 [95% CI 1.39-1.54]), pre-existing hypertension (AOR 4.28 [95% CI 4.15-4.42]) and chronic kidney disease (AOR 1.83 [95% CI 1.61-2.08]).

interpretationWomen with HIV are not at increased risk of maternal placental syndromes. Our results underscore the importance of optimizing the management of comorbid illness associated with maternal placental syndromes during the prenatal period for all women, irrespective of HIV status.

Identifiers

PMID26770960
PMCPMC4701653
OpenAlexW2265684553

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.