Evidence map›Paper›PMID 26770919›Full record

ReviewClinical and molecular hepatology2015

Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase.

Yasuko Iwakiri

Open access · goldAbstract readReview
In one paragraph

Review in Clinical and molecular hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 111 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Sinusoidal communication in chronic liver disease.Clinical and molecular hepatology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Frontiers in microbiology · 2024
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Nutrients · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Yasuko IwakiriDepartment of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.
Yale University · US

Funding

Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Richard A Flavell · 1993 to 2026
$44.0M
Arterial Remodeling in Chronic Liver DiseasesR01DK082600 · NIDDK · YALE UNIVERSITY · PI IWAKIRI, YASUKO · 2009 to 2014
$2.0M
Alcohol metabolism in liver sinusoidal endothelial cellsR21AA023599 · NIAAA · YALE UNIVERSITY · PI IWAKIRI, YASUKO · 2015 to 2016
$437k
NIAAA NIH HHS R21 AA023599NIAAA NIH HHS R21AA023599NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK082600
6 · The paper itself

Abstract

The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focusing on 1) iNOS biology, 2) iNOS-expressing liver cells, 3) iNOS-related therapeutic strategies, and 4) future directions.

Indexed as

Endothelial CellsHepatic Stellate CellsHumansKupffer CellsLiver CirrhosisNitric OxideNitric Oxide Synthase Type IIPolymorphism, Single NucleotideRNA, UntranslatedNitric OxideNitric Oxide Synthase Type IIRNA, UntranslatedHepatic stellate celliNOSKupffer cellLiver sinusoidal endothelial cellNO

Identifiers

PMID26770919
PMCPMC4712158
OpenAlexW2291913215

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.