Evidence map›Paper›PMID 26770731›Full record

ArticleSAGE open medicine2014

Family history of Alzheimer's disease limits improvement in cognitive function after bariatric surgery.

Michael L Alosco, Mary Beth Spitznagel, Gladys Strain, Michael Devlin, Ross D Crosby, James E Mitchell, John Gunstad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SAGE open medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Obesity in the Workplace: Impact, Outcomes, and Recommendations.Journal of occupational and environmental medicine · 2018
    Guideline
  4. Pooled it
  5. Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Adolescent weight history and adult cognition: before and after bariatric surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2016
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Michael L AloscoDepartment of Psychology, Kent State University, Kent, OH, USA.
Mary Beth SpitznagelDepartment of Psychology, Kent State University, Kent, OH, USA.
Gladys StrainWeill Cornell Medical College, Cornell University New York, NY, USA.
Michael DevlinEating Disorders Research Unit, Columbia University Medical Center, New York, NY, USA.
Ross D CrosbyNeuropsychiatric Research Institute, School of Medicine & Health Sciences, University of North Dakota, Fargo, ND, USA.
James E MitchellNeuropsychiatric Research Institute, School of Medicine & Health Sciences, University of North Dakota, Fargo, ND, USA.
John GunstadDepartment of Psychology, Kent State University, Kent, OH, USA.
Kent State University · USUniversity of North Dakota · USColumbia University Irving Medical Center · USCornell University · US

Funding

Cognitive Benefits of Cardiac Rehabilitation in Heart FailureR01HL089311 · NHLBI · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2008 to 2012
$2.6M
Cognitive Effects of Bariatric SurgeryR01DK075119 · NIDDK · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2006 to 2009
$1.5M
Extended Effects of Bariatric Surgery on Cognitive FunctionR56DK075119 · NIDDK · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2010 to 2010
$296k
NHLBI NIH HHS R01 HL089311NIDDK NIH HHS R01 DK075119NIDDK NIH HHS R56 DK075119
6 · The paper itself

Abstract

BACKGROUND/

objectiveBariatric surgery can reverse cognitive impairments associated with obesity. However, such benefits may be attenuated in individuals with a predisposing risk for cognitive impairment such as family history of Alzheimer's disease.

methodsIn all, 94 bariatric surgery participants completed a computerized cognitive test battery before and 12 weeks after surgery. Family history of Alzheimer's disease was obtained through self-report.

resultsIn the overall sample, cognitive function improved in memory and attention/executive function 12 weeks post-surgery. Repeated measures showed similar rates of improvements in attention/executive function between patients with and without a family history of Alzheimer's disease. In contrast, only individuals without a family history of Alzheimer's disease exhibited post-operative improvements in memory. A family history of Alzheimer's disease was associated with greater post-surgery rates of cognitive impairment.

conclusionsFamily history of Alzheimer's disease may limit post-surgery cognitive benefits. Future studies should examine whether weight loss can modify the course of cognitive decline in patients at-risk for Alzheimer's disease.

Indexed as

Alzheimer’s diseasebariatric surgerycognitive functionObesity

Identifiers

PMID26770731
PMCPMC4607206
OpenAlexW2157703794

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.