ArticleInternational journal of clinical and experimental medicine2015
Correlation between bone mineral density and serum trace element contents of elderly males in Beijing urban area.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Cuproptosis and Diabetic Osteoporosis: Mechanisms and Therapeutic Prospects.International journal of molecular sciences · 2026Review
- Sex differences in association of mixed exposure to blood cadmium, lead, mercury, selenium, manganese with osteoporosis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- ONMR: an orthopedic and nutritional Mendelian randomization database.NPJ science of food · 2025Article
- Associations between multiple metals exposure and bone mineral density: a population-based study in U.S. children and adolescents.BMC musculoskeletal disorders · 2025Article
- Association Between Combined Polymetallic Exposure and Osteoporosis.Biological trace element research · 2024Article
- Effects of Dietary Colostrum Basic Protein on Bone Growth and Calcium Absorption in Mice.Nutrients · 2024Article
- The Association between Serum Copper and Bone Mineral Density among Adolescents Aged 12 to 19 in the United States.Nutrients · 2024Article
- Associations of blood trace elements with bone mineral density: a population-based study in US adults.Journal of orthopaedic surgery and research · 2023Article
- Relationship of blood heavy metals and osteoporosis among the middle-aged and elderly adults: A secondary analysis from NHANES 2013 to 2014 and 2017 to 2018.Frontiers in public health · 2023Article
- Effect of Copper and Selenium Supplementation on the Level of Elements in Rats' Femurs under Neoplastic Conditions.Nutrients · 2022Article
- The Effects of Selenium on Bone Health: From Element to Therapeutics.Molecules (Basel, Switzerland) · 2022Review
- Relationships Between Indicators of Metabolic Disorders and Selected Concentrations of Bioelements and Lead in Serum and Bone Tissue in Aging Men.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- The concentrations of bone calcium, phosphorus and trace metal elements in elderly patients with intertrochanteric hip fractures.Frontiers in endocrinology · 2022Article
- Association between bone trace elements and osteoporosis in older adults: a cross-sectional study.Therapeutic advances in musculoskeletal disease · 2022Article
- Article
- The Effects of Calcium, Magnesium, Phosphorus, Fluoride, and Lead on Bone Tissue.Biomolecules · 2021Review
- Arsenic, cadmium, and selenium exposures and bone mineral density-related endpoints: The HORTEGA study.Free radical biology & medicine · 2021Article
- Article
- Association between Bone Mineral Density and Serum Iron Indices in Premenopausal Women in South Korea.Korean journal of family medicine · 2020Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trace element levels are associated with the incidence of osteoporotic fractures, but related mechanisms remain unknown. Trace elements may interfere with growth, development and maintenance of bones. Therefore, we investigated whether plasma trace element levels are associated with bone mineral density in elderly males in Beijing. After epidemiologically investigating 91 elderly males with age ranging from 50 years to 80 years, we obtained a total of 30 healthy (group 1), 31 osteopoenic (group 2) and 30 osteoporotic (group 3) subjects. Blood was collected, and serum concentrations of trace elements were detected. Elderly males in the three groups were carefully matched in terms of body mass index. Iron, manganese, zinc, copper, selenium, cadmium and lead were analysed by inductively coupled plasma-mass spectrometry. Bone mineral density (BMD) was measured by QDR-2000 dual-energy X-ray absorptiometry. Correlation between BMD and serum element contents was analysed using SPSS16.0. The plasma levels of manganese, zinc, copper, selenium and lead were similar in all of the groups (P>0.05). Cadmium was significantly and negatively correlated with BMD of the lumbar vertebrae (P<0.05). Moreover, cadmium and iron contents significantly differed in osteoporotic and healthy groups. These elements may directly and correlatively affect BMD in elderly males. Many trace elements may directly and correlatively influence BMD. Future studies should be conducted to evaluate serum and bone levels of these trace elements to determine the relationship of these trace elements with osteoporosis.
Indexed as
Identifiers
26770561PMC4694461W2253423002What OpenQuestion holds
Registered trials
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