Evidence map›Paper›PMID 26770523›Full record

ArticleInternational journal of clinical and experimental medicine2015

Electroacupuncture with different current intensities to treat knee osteoarthritis: a single-blinded controlled study.

Ziyong Ju, Xianhui Guo, Xu Jiang, Xin Wang, Shimin Liu, Jinsen He, Huashun Cui, Ke Wang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Acupuncture for hip osteoarthritis.The Cochrane database of systematic reviews · 2018
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Tackling Osteoarthritic Knee Pain with Electroacupuncture.Chinese journal of integrative medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ziyong JuCollege of Acumox and Tuina, Shanghai University of Traditional Chinese MedicineShanghai 201203, China; Department of Acupuncture, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203, China.
Xianhui GuoDepartment of Massage, Third Affiliated hospital of Henan University of Traditional Chinese Medicine Henan, China.
Xu JiangDepartment of Acupuncture, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
Xin WangLaboratory of Integrative Medicine Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203, China; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at ShanghaiShanghai 201203, China.
Shimin LiuCollege of Acumox and Tuina, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
Jinsen HeCollege of Acumox and Tuina, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
Huashun CuiDepartment of Acupuncture, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
Ke WangLaboratory of Integrative Medicine Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203, China; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at ShanghaiShanghai 201203, China.
Chinese National Human Genome Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo assess the efficacy of Electroacupuncture (EA) stimulation with high-intensity compared with low-intensity on knee osteoarthritis (KOA).

methodsParticipants with KOA were randomized to either high-intensity EA group or low-intensity EA group. EA was applied unilaterally on the affected leg with the local points GB34, ST34, EX-LE4, EX-LE5, ST36, and SP9. The visual analogue scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were measured before and after participation. Plasma TNFα, IL-1β, IL-6, and apelin levels were also assessed by enzyme immunoassay (ELA) before and after treatment.

resultsOf 80 participants who consented to study participation, 77 completed the program. The patients showed a significant improvement in their pain, stiffness, and physical function on the VAS and WOMAC, accompanying with a significantly reduction in plasma levels of apelin and TNFα. Furthermore, high-intensity group exhibited statistically significant improvements in stiffness and physical function symptoms compared with low-intensity group. Plasma level of IL-6 was significantly decreased only after high-intensity EA treatment. Furthermore, apelin level was significantly inhibited in high-intensity EA group than in low-intensity EA group.

conclusionsBoth high- and low-intensity EA treatments alleviate the clinical symptoms of KOA patients. High-intensity EA is more effective than low-intensity EA. Changes in plasma levels of TNFα, apelin and IL-6 may be involved in the therapeutic effect of EA on KOA.

Indexed as

current intensityElectroacupunctureknee osteoarthritispain

Identifiers

PMID26770523
PMCPMC4694423
OpenAlexW2401450959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.