ArticleInternational journal of clinical and experimental medicine2015
Lack of association between GSTP1 Ile105Val polymorphism and coronary heart disease risk: a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Association ofInternational journal of general medicine · 2020Article
- Cytology and molecular study for GSTP1 effect on asthma Iraqi patients.Clinical and molecular allergy : CMA · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many epidemiological studies have evaluated the association between GSTP1 Ile105Val polymorphism and coronary heart disease risk, but the results were inconsistent. This study aims re-evaluate the association between GSTP1 Ile105Val Polymorphism and coronary heart disease risk with a meta-analysis. We performed a search in the PubMed, Springer and Elsevier and ran a meta-analysis based on 8 case-control studies that included 3,888 cases and 3,476 controls. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association. The results showed that there was no significant association between GSTP1 Ile105Val Polymorphism and coronary heart disease risk susceptibility in the overall population (GG vs. AA: OR = 0.98, 95% CI = 0.84-1.15; GA vs. AA: OR = 1.04, 95% CI = 0.84-1.29; GA/GG vs. AA: OR = 1.02, 95% CI = 0.84-1.25; GG vs. AA/GA: OR = 0.94, 95% CI = 0.81-1.09). Subgroup analysis stratified by ethnicity and source of control showed no significant association with any genetic model. Our meta-analysis showed that GSTP1 Ile105Val polymorphisms might not be significantly associated with coronary heart disease risk.
Indexed as
Identifiers
26770457PMC4694357What OpenQuestion holds
Registered trials
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