ArticleInternational journal of clinical and experimental medicine2015
Expression and significance of TWIST, a zinc finger transcription factor, in laryngeal carcinoma among Chinese population: a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Magnesium Isoglycyrrhizinate Induces an Inhibitory Effect on Progression and Epithelial-Mesenchymal Transition of Laryngeal Cancer via the NF-κB/Twist Signaling.Drug design, development and therapy · 2020Article
- The Prognostic Value of Epithelial Membrane Protein 1 (EMP-1) in Patients with Laryngeal Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TWIST, an epithelial-mesenchymal transition inducer, has been implicated in the progression of a variety of cancers. Published evidence concerning the association of TWIST expression with laryngeal carcinoma risk has generated inconclusive results. Thus, we aimed to conduct a meta-analysis to address this controversy. A meta-analysis assessing the expression of TWIST in laryngeal cancer was conducted. Eligible studies for the period up to Jun 2015 were identified. After rigorous screening, a total of four studies met the inclusion criteria and they happened to be conducted on Chinese population. The results showed that TWIST positive expression rate in laryngeal cancer tissues was higher than that in normal tissues (OR=8.91, 95% CI=4.55-17.46). TWIST expression might have a correlation with low differentiation (OR=5.40, 95% CI=2.02-14.44), advanced clinical stage (OR=6.52, 95% CI=3.61-11.78), presence of lymph node metastasis (OR=9.10, 95% CI=4.26-19.41) and distant metastasis (OR=8.12, 95% CI=2.10-31.42), but not age and gender. The data suggested that TWIST might play critical roles in the development of laryngeal carcinoma. Further well-designed studies are warranted to get a more conclusive result.
Indexed as
Identifiers
26770438PMC4694338W2412805335What OpenQuestion holds
Registered trials
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