Evidence map›Paper›PMID 26770405›Full record

ArticleInternational journal of clinical and experimental medicine2015

Identifying the genes regulated by IDH1 via gene-chip in glioma cell U87.

Jie Ren, Meiqing Lou, Jinlong Shi, Yajun Xue, Daming Cui

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jie RenDepartment of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai, China.
Meiqing LouDepartment of Neurosurgery, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Jinlong ShiDepartment of Neurosurgery, Affiliated Hospital of Nantong University Nantong, Jiangsu Province, China.
Yajun XueDepartment of Neurosurgery, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Daming CuiDepartment of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai, China.
Shanghai First People's Hospital · CNShanghai Tenth People's Hospital · CNNantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma is the most common form of primary brain tumor. Increasing evidence show that IDH1 gene mutation is implicated in glioma. However, the mechanism involved in the progression of glioma remains unclear until now. In the study reported here, we used gene chip to identifying the genes regulated with IDH mutanted at R132. The results showed that IDH1-mutant leads to 1255 up-regulated genes and 1862 down-regulated genes in U87 cell lines. Meanwhile, GO and gene-network was performed and shown IDH1-mutant mainly affect small molecule metabolic process, mitotic cell cycle and apoptosis. This result will lay a foundation for further study of IDH1 gene function in the future.

Indexed as

gene-chipgene mutationGliomaIDH1overexpression

Identifiers

PMID26770405
PMCPMC4694305
OpenAlexW2412129377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.