ArticleInternational journal of clinical and experimental medicine2015
Association between the COMT 158 G/A polymorphism and lung cancer risk: a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Cytogenetic Consequences of Food Industry Workers Occupationally Exposed to Cooking Oil Fumes (COFs).Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Interaction Between Environmental Risk Factors and Catechol-O-Methyltransferase (COMT) and X-Ray Repair Cross-Complementing Protein 1 (XRCC1) Gene Polymorphisms in Risk of Lung Cancer Among Non-Smoking Chinese Women: A Case-Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catechol-O-methyltransferase (COMT) 158 G/A gene polymorphism seem to associate with lung cancer, but the results are inconclusive. This meta-analysis aims to investigate the association between COMT 158 G/A gene polymorphism and lung cancer susceptibility. We searched PubMed, Embase, China National Knowledge Infrastructure (CNKI), VIP Chinese science and technology periodical database (VIP) and Wanfang databases up to March 25, 2015 for articles on the connection between the COMT 158 G/A polymorphism and the risk of lung cancer. Pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were used to estimate the connection. STATA (Version 12.0) was adopted for data analysis. Overall, 6 articles of 7 studies including 2,293 cases and 2,768 controls were included in our meta-analysis. In general analysis, no significant association was found between COMT 158 G/A polymorphism and the risk of lung cancer (AA + AG vs. GG: OR 1.14, 95% CI 0.90-1.44, P=0.28). However, in subgroup analysis of different method of genotyping, we found significant increase of lung cancer risk (OR 1.30, 95% CI 1.04-1.62, I(2)=61.5%, P=0.02), also there was significant association between COMT 158 G/A polymorphism and the risk of lung cancer in Chinese non-smoker women of unsorted cancer type (OR 1.48, 95% CI 1.24-1.77, I(2)=0%, P=0.00). The study indicates that COMT 158 G/A G->A gene transition might contribute to lung cancer, especially in Chinese non-smoker women.
Indexed as
Identifiers
26770364PMC4694264W2440142570What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.