Evidence map›Paper›PMID 26770352›Full record

ArticleInternational journal of clinical and experimental medicine2015

Association of interleukin-17 gene polymorphisms and Helicobacter pylori infection with gastric cancer susceptibility: a cumulative and comprehensive meta-analysis.

Xue-Feng Li, Ming Shen, Jun-Wei Cai, Yu-Qin Zeng, Min Li, Gong-Li Yang, Xiao-Ming Xu, Yuan-Yuan Hu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Association Between the CD28 c.17 +3 T>C Polymorphism (rs3116496) and Cancer Risk: An Updated Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. T Cell Cytokines Impact Epithelial Cell Responses duringJournal of immunology (Baltimore, Md. : 1950) · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xue-Feng LiDepartment of Endocrinology, Taihe Hospital, Hubei University of Medicine Shiyan 442000, P. R. China.
Ming ShenJiangsu Key Laboratory of Oral Diseases, Department of Dental Implant, Affiliated Hospital of Stomatology, Nanjing Medical University No. 140 Hanzhong Road, Nanjing 210029, P. R. China.
Jun-Wei CaiDepartment of Endocrinology, Taihe Hospital, Hubei University of Medicine Shiyan 442000, P. R. China.
Yu-Qin ZengDepartment of Endocrinology, Taihe Hospital, Hubei University of Medicine Shiyan 442000, P. R. China.
Min LiDepartment of Endocrinology, Taihe Hospital, Hubei University of Medicine Shiyan 442000, P. R. China.
Gong-Li YangDepartment of Gastroenterology, Taihe Hospital, Hubei University of Medicine 32 South Renmin Road, Shiyan 442000, P. R. China.
Xiao-Ming XuDepartment of Stomatology, Taihe Hospital, Hubei University of Medicine, Center for Evidence-Based Medicine and Clinical Research Shiyan 442000, P. R. China.
Yuan-Yuan HuDepartment of Stomatology, Taihe Hospital, Hubei University of Medicine, Center for Evidence-Based Medicine and Clinical Research Shiyan 442000, P. R. China.
Hubei University of Medicine · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between Interleukin-17(IL-17) gene polymorphisms and Helicobacter pylori (H. pylori) infection and gastric cancer susceptibility were inconsistent. We therefore performed a comprehensive meta-analysis about all three genetic polymorphisms of IL-17 to derive a more precise estimation.

methodsPubMed, Embase, CNKI and Wanfang databases were researched on the associations between IL-17A rs2275913G>A, rs3748067C>T and IL-17F rs763780 T>C and gastric cancer risk. Odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the relationships. Publication bias, sensitivity and cumulative analysis was conducted to guarantee the strength of meta-analysis.

resultsOverall, eleven related studies involving 4,478 cases and 5,612 controls were collected. Significantly increased risk between IL-17A rs2275913G>A polymorphism and gastric cancer were observed (A vs. G: OR = 1.22, 95% CI = 1.08-1.37, P<0.01, I(2) = 72.3%; AA vs. GG: OR = 1.55, 95% CI = 1.21-1.99, P<0.01, I(2) = 74.3%; GA + AA vs. GG: OR = 1.19, 95% CI = 1.05-1.39, P<0.01, I(2) = 48.2%; AA vs. GG + GA: OR = 1.50, 95% CI = 1.16-1.95, P<0.01, I(2) = 81.2%). For IL-17F rs3748067C>T and rs763780 T>C polymorphisms, only few significantly increased risk could be found in genetic models. Moreover, H. pylori infection also be proved to increase the risk of gastric cancer combined with rs3748067C>T mutation.

conclusionsOur meta-analysis suggests that the three IL-17 polymorphisms were associated with a significantly increased risk of gastric cancer, especially in Chinese.

Indexed as

Helicobacter pyloriInterleukin-17polymorphismstomach neoplasm

Identifiers

PMID26770352
PMCPMC4694252
OpenAlexW2396560477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.