ArticleInternational journal of clinical and experimental medicine2015
Up-regulation of Dectin-1 in airway epithelial cells promotes mice defense against invasive pulmonary aspergillosis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- The immune response of upper and lower airway epithelial cells to Aspergillus fumigatus and Candida albicans-derived β-glucan in Th17 type cytokine environment.Archives of microbiology · 2025Article
- Characterization of fungal exposure and dectin-1 expression in healthy horses and horses with severe asthma.American journal of veterinary research · 2022Article
- Epigenetic regulation of epithelial dectin-1 through an IL-33-STAT3 axis in allergic disease.Allergy · 2022Article
- Differential Proinflammatory Responses toJournal of fungi (Basel, Switzerland) · 2021Article
- Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-CausingFrontiers in immunology · 2020Review
- Fungal Pathogens in CF Airways: Leave or Treat?Mycopathologia · 2018Review
- Dectin-2 Is a C-Type Lectin Receptor that Recognizes Pneumocystis and Participates in Innate Immune Responses.American journal of respiratory cell and molecular biology · 2018Article
- Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease.Journal of fungi (Basel, Switzerland) · 2018Review
- Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.EMBO molecular medicine · 2017Review
- The Interaction ofJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Fungal Microbiota in Chronic Airway Inflammatory Disease and Emerging Relationships with the Host Immune Response.Frontiers in microbiology · 2017Article
- Aspergillosis and stem cell transplantation: An overview of experimental pathogenesis studies.Virulence · 2016Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWith the growing number of immunocompromised patients, the incidence of invasive pulmonary aspergillosis increases. Innate immunity plays a significant role in defensing against fungal infection. Airway epithelial cells induce immune responses like the production of cytokine and chemokine via Dectin-1 signaling pathway in response to Aspergillus fumigatus. Thus, we hypothesized that up-regulation of Dectin-1 on airway epithelium cells would promote the defense against A. fumigatus.
methodsWe designed an adenoviral vector encoding full-length Dectin-1, and then transfected it into mice airway epithelial cells via intratracheal injection before the invasion of A. fumigatus. Transfect mice model was verified by using real-time PCR and immunohistochemistry. And also, we studied the effects of up-regulation of Dectin-1 on the production of proinflammatory cytokines, histological changes, fungal burden and survival rate during A. fumigatus infection.
resultsThe expression level of Dectin-1 in lungs of mice with Dectin-1 recombinant adenoviral vector significantly increased. And also, the mice had higher production of TNF-α, GM-CSF and IL-1β, lower fungal burden, more recruitment of neutrophils into lungs and higher survival rate in response to A. fumigatus infection.
conclusionsThe administration of Dectin-1 recombinant adenoviral vector through trachea can elevate the expression of Dectin-1 on airway epithelium, and also, its function during the course of A. fumigatus infection was demonstrated.
Indexed as
Identifiers
26770339PMC4694239W2407102519What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.